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Synthesis and evaluation of substituted 5-(3-chloro-2-oxo-4-phenylazetidin-1-ylamino)pyrimidine-2,4,6(1H,3H,5H)-triones against pentylenetetrazole-induced convulsant in mice

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Abstract

This study was designed to synthesis of substituted 5-(3-chloro-2-oxo-4-phenylazetidin-1-ylamino)pyrimidine-2,4,6(1H,3H,5H)-triones followed by evaluation against pentylenetetrazole-(PTZ) induced convulsant in mice. The titled compounds were confirmed by IR and 1H-NMR spectral techniques. Pre-treatment of compound 4c showed significant anticonvulsant activity at 40 mg/kg which was comparable to that of PTZ and sodium valproate pre-treated groups. The results show the importance of barbituric acid derivative (i.e., compound 4c (R = p-OH, m-OCH3) for this anti-convulsant activity. It may be due to its anti-oxidative and neuroprotective potential. Therefore, compound 4c emerged as the most active molecules in the management of convulsive disorder.

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Acknowledgment

Thanks to Dr. A.C. Rana and all faculty members of Rayat Institute of Pharmacy for their encouragement and support. We are also grateful to Rayat & Bahra Educational and Research Trust for their unconditional help to carry out this project.

Conflict of interest

There was no conflict of interest in this study.

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Author notes

  1. Arunachalam Muthuraman

    Present address: Department of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, Punjab, 147002, India

Authors and Affiliations

  1. Rayat Institute of Pharmacy, Nawanshahr District, Near Ropar, Railmajra, Punjab, 144533, India

    Karan Deep Singh Puri, Shailja Sood & Arunachalam Muthuraman

  2. Rayat Institute of Pharmacy, District Shaheed Bhagat Singh Nagar, Railmajra, Punjab, 144533, India

    Arunachalam Muthuraman

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  1. Karan Deep Singh Puri
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  2. Shailja Sood
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Correspondence to Arunachalam Muthuraman.

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Puri, K.D.S., Sood, S. & Muthuraman, A. Synthesis and evaluation of substituted 5-(3-chloro-2-oxo-4-phenylazetidin-1-ylamino)pyrimidine-2,4,6(1H,3H,5H)-triones against pentylenetetrazole-induced convulsant in mice. Med Chem Res 21, 2300–2306 (2012). https://doi.org/10.1007/s00044-011-9760-8

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  • DOI: https://doi.org/10.1007/s00044-011-9760-8

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