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Synthesis of 1-(4-((E)-3-arylacryloyl) phenyl)-3,4-dibromo-1H-pyrrole-2,5-diones and screening for anti-Candida and antituberculosis activity

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Abstract

A series of eleven 1-(4-((E)-3-arylacryloyl) phenyl)-3,4 dibromo-1H-pyrrole-2,5-diones (4′-aminochalcone-based dibromomaleimides) were synthesized using maleic anhydride and p-aminoacetophenone as starting material. Furthermore, there has been some additional work investigating the effect of these derivatives on biological activity. They were characterized using FTIR, 1H NMR, 13C NMR, ESI mass spectroscopy, and elemental analysis. The compounds show anti-Candida & antituberculosis activity.

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Acknowledgments

The author wish to thank the Department of Applied Chemistry, SVNIT, Surat, for providing laboratory facilities and D. P. Rajani, Microcare Laboratory, Surat, for antimicrobial activity determinations. Analytical facilities providing by the Centre of Excellence, Vapi, Oxygen Healthcare Research Lab, Ahmedabad, and Central Salt & Marine Chemicals Research Institute, Bhavnagar, Gujarat, India, are gratefully acknowledged.

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  1. Department of Applied Chemistry, S.V. National Institute of Technology, Ichchhanath, Surat, 395007, Gujarat, India

    J. R. Patel & B. Z. Dholakiya

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  1. J. R. Patel
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  2. B. Z. Dholakiya
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Correspondence to B. Z. Dholakiya.

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Patel, J.R., Dholakiya, B.Z. Synthesis of 1-(4-((E)-3-arylacryloyl) phenyl)-3,4-dibromo-1H-pyrrole-2,5-diones and screening for anti-Candida and antituberculosis activity. Med Chem Res 21, 1977–1983 (2012). https://doi.org/10.1007/s00044-011-9718-x

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