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Antimycobacterial activity of fractions and isolated compounds from Vetiveria zizanioides

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Abstract

The essential oil of Vetiveria zizanioides showed significant antimycobacterial activity against the drug-resistant strains of Mycobacterium smegmatis, which on activity guided fractionation afforded four bioactive fractions Vz-2, Vz-7, Vz-8, and Vz-9. Further purification of these bioactive fractions over preparative thin layer chromatographic resulted in the characterization of six compounds: 5, 10-pentadecadiyn-1-ol (1), α-curcumene (3), hydroxy junipene (4), (+) cycloisosativene (5), valencine (6), and selino 3,7 (11)-diene (7). All these compounds showed significant antimycobacterial activity against the drug-resistant strains (MDR-R and MDR-40) of M. smegmatis and their MIC was in the range of 31.25–62.5 μg/ml. These results may be of great help in antimycobacterial drug development from a very common, inexpensive, and non toxic natural product.

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Acknowledgments

Financial support for this research by the Council of Scientific & Industrial Research (CSIR) is gratefully acknowledged. We also thank all of our colleagues for their excellent assistance.

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Authors and Affiliations

  1. Analytical Chemistry Division, Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow, 226015, India

    Shikha Gupta & Santosh K. Srivastava

  2. Molecular Bioprospection Department, Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow, 226015, India

    Gaurav R. Dwivedi & Mahendra P. Darokar

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  1. Shikha Gupta
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  2. Gaurav R. Dwivedi
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  3. Mahendra P. Darokar
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  4. Santosh K. Srivastava
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Correspondence to Santosh K. Srivastava.

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Gupta, S., Dwivedi, G.R., Darokar, M.P. et al. Antimycobacterial activity of fractions and isolated compounds from Vetiveria zizanioides . Med Chem Res 21, 1283–1289 (2012). https://doi.org/10.1007/s00044-011-9639-8

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  • DOI: https://doi.org/10.1007/s00044-011-9639-8

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