Abstract
Controlling blood sugar levels is crucial for diabetic patients and is managed through administration of drugs such as gliquidone. Coadministration of antidiabetic drugs with H1-receptor antagonists is common but is also a source of concern due to potential coadministered drug interaction, especially in patients prone to allergic disorders. In this work, we describe in vitro drug interactions of gliquidone with commonly coadministered H1-receptor antagonists (fexofenadine hydrochloride, cetirizine dihydrochloride, and levocetirizine dihydrochloride). These studies were performed at 37°C in different pH environments simulating human body compartments using UV spectrophotometry and high performance liquid chromatography (HPLC). It was observed that the percentage availability values of gliquidone and H1-receptor antagonists were not affected in the presence of each other. No significant difference between gliquidone and H1-receptor antagonists and no remarkable changes in availability values were observed when these interactions were studied using UV–visible and HPLC techniques. This study thus supports the safe coadministration of gliquidone and H1-receptor blockers as an effective diabetic health management regimen.
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Acknowledgments
The authors acknowledge the Higher Education Commission of Pakistan for providing financial support to Agha Zeeshan Mirza under Indigenous Ph.D. 5000 Scholarship Program Batch II. The authors are thankful to Aeraj ul Haque, Bindley Bioscience Centre, Purdue University, for his help with the manuscript.
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Arayne, M.S., Sultana, N., Shamshad, H. et al. Drug interaction studies of gliquidone with fexofenadine, cetirizine, and levocetirizine. Med Chem Res 19, 1064–1073 (2010). https://doi.org/10.1007/s00044-009-9252-2
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DOI: https://doi.org/10.1007/s00044-009-9252-2