Abstract
A new series of 2-[(chlorobenzyl)thio]-5-(5-nitro-2-furyl)-1,3,4-thiadiazoles (6a–h) were synthesized and evaluated by the disc diffusion method against Helicobacter pylori. Four compounds which exhibited strong anti-H. pylori activity at concentration of 8–32 μg/disc (average of inhibition zone >20 mm) were further tested against 20 clinical isolates of H. pylori at lower concentrations. The averages of inhibition zone diameters indicated that all selected compounds exhibit better anti-H. pylori activity profile against clinical isolates of H. pylori with respect to standard drug metronidazole. Compound 6c, containing the 3-chlorobenzylthio moiety, was the most potent compound tested.
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This work was supported by grants from the Islamshahr Young Researchers Club, Islamic Azad University, and the Iran National Sciences Foundation (INSF).
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Mohammadhosseini, N., Letafat, B., Siavoshi, F. et al. Synthesis and in vitro anti-Helicobacter pylori activity of 2-[(chlorobenzyl)thio]-5-(5-nitro-2-furyl)-1,3,4-thiadiazoles. Med Chem Res 17, 578–586 (2008). https://doi.org/10.1007/s00044-008-9099-y
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DOI: https://doi.org/10.1007/s00044-008-9099-y