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Radical scavenging capacities of some thiazolylthiazolidine-2,4-dione derivatives

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Abstract

In this study, a series of 2,4-dichlorothiazolyl thiazolidine-2,4-dione (Ia-f) and 4-chloro-2-benzylsulfanylthiazolyl-thiazolidine-2,4-dione derivatives (IIa-f) were tested for their antioxidant properties by determining their effects on superoxide anion formation, and the 2,2-diphenyl-1-picrylhydrazyl (DPPH) stable free radical. Compound Ic showed the best superoxide anion scavenging activity at the 10−3 M and 10−4 M concentrations. The compounds (Ia-f and IIa-f) had the strong DPPH radical scavenger capacity at the 10−3 M concentration. Compound Ib, Id, and Ie showed similar activity to butylated hydroxytoluene (BHT) at 10−3 M and 10−4 M concentrations.

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Acknowledgement

This work was supported by Research Organization of Ankara University, Turkey (no. 2005-0803048)

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100, Tandogan, Ankara, Turkey

    Oya Bozdağ-Dündar, Meltem Ceylan-Ünlüsoy & Rahmiye Ertan

  2. Department of Toxicology, Faculty of Pharmacy, Ankara University, 06100, Tandogan, Ankara, Turkey

    Tülay Çoban

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  1. Oya Bozdağ-Dündar
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  2. Tülay Çoban
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  3. Meltem Ceylan-Ünlüsoy
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  4. Rahmiye Ertan
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Correspondence to Oya Bozdağ-Dündar.

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Bozdağ-Dündar, O., Çoban, T., Ceylan-Ünlüsoy, M. et al. Radical scavenging capacities of some thiazolylthiazolidine-2,4-dione derivatives. Med Chem Res 18, 1–7 (2009). https://doi.org/10.1007/s00044-007-9081-0

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  • DOI: https://doi.org/10.1007/s00044-007-9081-0

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