Abstract
The T lymphocyte has a vital part to play in maintaining the host response to bacterial and viral infection and also appears to play a key pathological role in autoimmune diseases such as rheumatoid arthritis. In this review, we summarize the signalling pathways which trigger antigen-driven T-cell proliferation and examine the evidence which suggests that protein kinase C (PKC) is fundamental to this process. Finally, we discuss the therapeutic potential that PKC inhibitors may have in the treatment of autoimmune disease.
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Received 31 March 1998; received after revision 19 May 1998; accepted 19 May 1998
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Wilkinson, S., Nixon, J. T-cell signal transduction and the role of protein kinase C. CMLS, Cell. Mol. Life Sci. 54, 1122–1144 (1998). https://doi.org/10.1007/s000180050241
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DOI: https://doi.org/10.1007/s000180050241