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Caenorhabditis elegans: a model to understand host–microbe interactions

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Abstract

Host–microbe interactions within the gut are fundamental to all higher organisms. Caenorhabditis elegans has been in use as a surrogate model to understand the conserved mechanisms in host–microbe interactions. Morphological and functional similarities of C. elegans gut with the human have allowed the mechanistic investigation of gut microbes and their effects on metabolism, development, reproduction, behavior, pathogenesis, immune responses and lifespan. Recent reports suggest their suitability for functional investigations of human gut bacteria, such as gut microbiota of healthy and diseased individuals. Our knowledge on the gut microbial diversity of C. elegans in their natural environment and the effect of host genetics on their core gut microbiota is important. Caenorhabditis elegans, as a model, is continuously bridging the gap in our understanding the role of genetics, environment, and dietary factors on physiology of the host.

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Acknowledgements

The author AK is a recipient of junior research fellowship (DBT/JRF/BET-16/I/2016/AL/143) from Department of Biotechnology (DBT), Government of India. Caenorhabditis elegans has been established at the Institute of Advanced Study in Science and Technology (IASST) with the Grant from DBT under Unit of excellence project (BT/NE/550/U-EXCEL). We thank Dr. Atanu Adak for his useful comments on the manuscript. We are also thankful to Mr. William Barbeau (Lab Technician, School of Medicine, University of Utah, Salt Lake City, UT 84112, United States of America) for helping us in improving the English grammar of the manuscript.

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Authors and Affiliations

  1. Molecular Biology and Microbial Biotechnology Laboratory, Division of Life Sciences, Institute of Advanced Study in Science and Technology (IASST), Guwahati, Assam, 781035, India

    Arun Kumar & Mojibur Khan

  2. Department of Agricultural Biotechnology, Assam Agricultural University, Jorhat, Assam, 785013, India

    Aiswarya Baruah

  3. Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, 113-0033, Japan

    Masahiro Tomioka & Yuichi Iino

  4. JST, CREST, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan

    Yuichi Iino

  5. Department of Biotechnology, Gauhati University, Guwahati, Assam, 781014, India

    Mohan C. Kalita

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  1. Arun Kumar
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Kumar, A., Baruah, A., Tomioka, M. et al. Caenorhabditis elegans: a model to understand host–microbe interactions. Cell. Mol. Life Sci. 77, 1229–1249 (2020). https://doi.org/10.1007/s00018-019-03319-7

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