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The mesenchymoangioblast, mesodermal precursor for mesenchymal and endothelial cells

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Abstract

Mesenchymoangioblast (MB) is the earliest precursor for endothelial and mesenchymal cells originating from APLNR+PDGFRα+KDR+ mesoderm in human pluripotent stem cell cultures. MBs are identified based on their capacity to form FGF2-dependent compact spheroid colonies in a serum-free semisolid medium. MBs colonies are composed of PDGFRβ+CD271+EMCN+DLK1+CD73− primitive mesenchymal cells which are generated through endothelial/angioblastic intermediates (cores) formed during first 3–4 days of clonogenic cultures. MB-derived primitive mesenchymal cells have potential to differentiate into mesenchymal stromal/stem cells (MSCs), pericytes, and smooth muscle cells. In this review, we summarize the specification and developmental potential of MBs, emphasize features that distinguish MBs from other mesenchymal progenitors described in the literature and discuss the value of these findings for identifying molecular pathways leading to MSC and vasculogenic cell specification, and developing cellular therapies using MB-derived progeny.

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Abbreviations

MB:

Mesenchymoangioblast

HB:

Hemangioblast

PC:

Pericytes

SMC:

Smooth muscle cells

MSC:

Mesenchymal stem/stromal cells

hPSC:

Human pluripotent stem cells

hESC:

Human embryonic stem cells

hiPSCs:

Human-induced pluripotent stem cells

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Acknowledgements

We thank Matthew Raymond for editorial assistance. I.I.S. and A.K are supported by funds from the National Institute of Health (U01HL134655, U01HL099773 and P51 RR000167). I.I.S. is a founding shareholder and consultant for Cynata Therapeutics.

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  1. Wisconsin National Primate Research Center, University of Wisconsin, 1220 Capitol Ct., Madison, WI, 53715, USA

    Igor I. Slukvin & Akhilesh Kumar

  2. Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, 53707, USA

    Igor I. Slukvin

  3. Department of Pathology and Laboratory Medicine, University of Wisconsin, 1685 Highland Ave, Madison, WI, 53705, USA

    Igor I. Slukvin

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  1. Igor I. Slukvin
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Slukvin, I.I., Kumar, A. The mesenchymoangioblast, mesodermal precursor for mesenchymal and endothelial cells. Cell. Mol. Life Sci. 75, 3507–3520 (2018). https://doi.org/10.1007/s00018-018-2871-3

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  • DOI: https://doi.org/10.1007/s00018-018-2871-3

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