Abstract
In plants, mitogen-activated protein kinase (MAPK) cascades are involved in regulating many biological processes including immunity. They relay signals from membrane-residing immune receptors to downstream components for defense activation. Arabidopsis MPK3/6 and MPK4 are activated in two parallel MAPK cascades during PAMP-triggered immunity. MPK3/6 have been implicated in the activation of various immune responses and their inactivation leads to compromised defense against pathogens. On the other hand, the MEKK1-MKK1/2-MPK4 cascade plays critical roles in basal resistance. Disruption of this MAPK cascade results in constitutive defense responses mediated by the NB-LRR protein SUMM2. Interestingly, SUMM2 guards the MEKK1-MKK1/2-MPK4 cascade activity indirectly through monitoring the phosphorylation status of CRCK3, which is a substrate of MPK4. From the pathogens’ side, a number of effectors are shown to target various components of MAPK cascades in plants. Inactivation of MPK4 by the Pseudomonas effector HopAI1 triggers SUMM2-mediated immunity. Together, these findings suggest intricate interplays between PAMP-triggered immunity and effector-triggered immunity via MAPK signaling.
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Abbreviations
- FLS2:
-
FLAGELLIN-SENSITIVE2
- EFR:
-
Elongation factor (EF)-TU receptor
- BAK1:
-
BRI1-associated receptor kinase1
- RLCKs:
-
Receptor-like cytoplasmic kinases
- MEKK:
-
MAPK/ERK kinase kinase
- MKK:
-
MAP kinase kinase
- MPK:
-
MAP kinase
- CRCK3:
-
Calmodulin-binding receptor-like cytoplasmic kinase 3
- SUMM2:
-
Suppressor of mkk1 mkk2 2
- MKS1:
-
MAP kinase substrate 1
- WRKY33:
-
WRKY DNA-binding protein 33
- ACS:
-
1-Amino-cyclopropane-1-carboxylate synthase
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The authors would like to thank financial supports from CFI and NSERC-Discovery program.
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Thulasi Devendrakumar, K., Li, X. & Zhang, Y. MAP kinase signalling: interplays between plant PAMP- and effector-triggered immunity. Cell. Mol. Life Sci. 75, 2981–2989 (2018). https://doi.org/10.1007/s00018-018-2839-3
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DOI: https://doi.org/10.1007/s00018-018-2839-3