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Metabolic effects of resveratrol: addressing the controversies

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Abstract

Resveratrol, a polyphenol found in a number of plant-based foods such as red wine, has received a great deal of attention for its diverse array of healthful effects. Beneficial effects of resveratrol are diverse; they include improvement of mitochondrial function, protection against obesity and obesity-related diseases such as type-2 diabetes, suppression of inflammation and cancer cell growth and protection against cardiovascular dysfunction, just to name a few. Investigations into the metabolic effects of resveratrol are furthest along and now include a number of clinical trials, which have yielded mixed results. There are a number of controversies surrounding resveratrol that have not been resolved. Here, we will review these controversies with particular emphasis on its mechanism of metabolic action and how lessons from resveratrol may help develop therapies that harness the effects of resveratrol but without the undesirable properties of resveratrol.

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Abbreviations

AMPK:

Adenosine monophosphate activated kinase

Sirt1:

Sirtuin 1

SIR2:

Silent information regulator 2

cAMP:

Cyclic adenosine monophosphate

CAMKKβ:

Calcium/calmodulin-dependent kinase kinase β

PDE:

Phosphodiesterases

PKA:

Protein kinase A

EPAC:

Exchange protein activated by cAMP

COX:

Cyclooxygenase

HOMA-IR:

Homeostatic model assessment-insulin resistance

eNOS:

Endothelial nitric oxide synthase

Nrf2:

Nuclear factor erythroid 2- related factor 2

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Acknowledgments

This work was supported by the Intramural Research Program, National Heart Lung and Blood Institute, National Institutes of Health. We thank Alexandra Brown for manuscript preparation.

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  1. Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, 10 Center Drive Building 10 Room 7D14, Bethesda, MD, 20892, USA

    Jacob L. Bitterman & Jay H. Chung

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Bitterman, J.L., Chung, J.H. Metabolic effects of resveratrol: addressing the controversies. Cell. Mol. Life Sci. 72, 1473–1488 (2015). https://doi.org/10.1007/s00018-014-1808-8

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  • DOI: https://doi.org/10.1007/s00018-014-1808-8

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