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IL-18 in inflammatory and autoimmune disease

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Abstract

Inflammation serves as the first line of defense in response to tissue injury, guiding the immune system to ensure preservation of the host. The inflammatory response can be divided into a quick initial phase mediated mainly by innate immune cells including neutrophils and macrophages, followed by a late phase that is dominated by lymphocytes. Early in the new millennium, a key component of the inflammatory reaction was discovered with the identification of a number of cytosolic sensor proteins (Nod-like receptors) that assembled into a common structure, the ‘inflammasome’. This structure includes an enzyme, caspase-1, which upon activation cleaves pro-forms of cytokines leading to subsequent release of active IL-1 and IL-18. This review focuses on the role of IL-18 in inflammatory responses with emphasis on autoimmune diseases.

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Acknowledgments

We thank the Swedish Research Council, Torsten Söderberg foundation, Swedish Cancer foundation, King V’s 80 year foundation, Swedish Rheumatism association, Theme Centre for Cardiovascular Research, Karolinska Instituet, Swedish Society for Medical Research (SSMF), O.E. and Edla Johanssons Foundation, Center for Allergy Research at Karolinska Institutet (CfA), Svenska Sällskapet för Medicinsk Forskning and Olle Engkvist Foundations for research grant support. T.H. is supported by a PhD fellowship from Karolinska Institutet.

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  1. Department of Medicine-Solna, Translational Immunology Unit, Karolinska Institutet, Karolinska University Hospital Solna, L2:04, 171 76, Stockholm, Sweden

    Saikiran K. Sedimbi, Thomas Hägglöf & Mikael C. I. Karlsson

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  1. Saikiran K. Sedimbi
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Correspondence to Saikiran K. Sedimbi or Mikael C. I. Karlsson.

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Sedimbi, S.K., Hägglöf, T. & Karlsson, M.C.I. IL-18 in inflammatory and autoimmune disease. Cell. Mol. Life Sci. 70, 4795–4808 (2013). https://doi.org/10.1007/s00018-013-1425-y

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