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AMPAR trafficking in synapse maturation and plasticity

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Abstract

Glutamate ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors (AMPARs) mediate most fast excitatory synaptic transmission in the central nervous system. The content and composition of AMPARs in postsynaptic membranes (which determine synaptic strength) are dependent on the regulated trafficking of AMPAR subunits in and out of the membranes. AMPAR trafficking is a key mechanism that drives nascent synapse development, and is the main determinant of both Hebbian and homeostatic plasticity in mature synapses. Hebbian plasticity seems to be the biological substrate of at least some forms of learning and memory; while homeostatic plasticity (also known as synaptic scaling) keeps neuronal circuits stable by maintaining changes within a physiological range. In this review, we examine recent findings that provide further understanding of the role of AMPAR trafficking in synapse maturation, Hebbian plasticity, and homeostatic plasticity.

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Acknowledgments

This work was supported by Fondazione Telethon grants GGP12097; GGP11116 and Fondation Jérôme Lejeune to M.P.

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Authors and Affiliations

  1. CNR Institute of Neuroscience, Department of Medical Pharmacology, University of Milan, Milan, Italy

    Silvia Bassani, Alessandra Folci, Jonathan Zapata & Maria Passafaro

  2. Dulbecco Telethon Institute, Rome, Italy

    Maria Passafaro

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  1. Silvia Bassani
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  2. Alessandra Folci
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  3. Jonathan Zapata
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  4. Maria Passafaro
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Corresponding author

Correspondence to Maria Passafaro.

Additional information

S. Bassani, A. Folci, and J. Zapata contributed equally to this work.

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Bassani, S., Folci, A., Zapata, J. et al. AMPAR trafficking in synapse maturation and plasticity. Cell. Mol. Life Sci. 70, 4411–4430 (2013). https://doi.org/10.1007/s00018-013-1309-1

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  • DOI: https://doi.org/10.1007/s00018-013-1309-1

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