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A therapeutic role for vitamin D on obesity-associated inflammation and weight-loss intervention

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Abstract

Vitamin D plays an essential role in the regulation of skeletal metabolism as well as calcium and phosphate homeostasis, while vitamin D receptor (VDR) regulates de novo lipid synthesis, thereby contributing to the development of obesity. Furthermore, obese individuals are at a greater risk for vitamin D deficiency which may increase the potential risk for chronic inflammation, insulin resistance, and metabolic syndrome. While acute exercise enhances the activation of inflammatory signaling pathways, chronic exercise training may attenuate elevated pro-inflammatory cytokine production, resulting in the improvement of cardiovascular and metabolic health in obese individuals. Supplementation with vitamin D coupled with exercise or mild caloric restriction has been shown to improve markers of fitness and inflammation as well as cholesterol. Therefore, this review primarily addresses the impact of vitamin D deficiency in obesity-related inflammatory imbalances and how exercise and weight-loss interventions may enhance the beneficial effects on vitamin D-mediated inflammation in obesity.

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Acknowledgments

The authors would like to thank Mr. J. Thomas Mock and Ms. Kathrine M. McFarland for their contributions to this paper.

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Authors and Affiliations

  1. Department of Kinesiology and Health Sciences, Virginia Commonwealth University, 1020 West Grace Street, Richmond, VA, 23284, USA

    Aaron L. Slusher

  2. Department of Kinesiology, Mississippi State University, Mississippi State, MS, USA

    Matthew J. McAllister

  3. Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL, USA

    Chun-Jung Huang

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  1. Aaron L. Slusher
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  2. Matthew J. McAllister
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  3. Chun-Jung Huang
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Correspondence to Aaron L. Slusher.

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Slusher, A.L., McAllister, M.J. & Huang, CJ. A therapeutic role for vitamin D on obesity-associated inflammation and weight-loss intervention. Inflamm. Res. 64, 565–575 (2015). https://doi.org/10.1007/s00011-015-0847-4

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