Abstract
Longevity and aging are two sides of the same coin, as they both derive from the interaction between genetic and environmental factors. Aging is a complex, dynamic biological process characterized by continuous remodeling. One of the most recent theories on aging focuses on immune response, and takes into consideration the activation of subclinical, chronic low-grade inflammation which occurs with aging, named “inflammaging”. Long-lived people, especially centenarians, seem to cope with chronic subclinical inflammation through an anti-inflammatory response, called therefore “anti-inflammaging”. In the present review, we have focused our attention on the contrast between inflammaging and anti-inflammaging systems, by evaluating the role of cytokines and their impact on extreme longevity. Cytokines are the expression of a network involving genes, polymorphisms and environment, and are involved both in inflammation and anti-inflammation. We have described the role of IL-1, IL-2, IL-6, IL-12, IL-15, IL-18, IL-22, IL-23, TNF-α, IFN-γ as pro-inflammatory cytokines, of IL-1Ra, IL-4, IL-10, TGF-β1 as anti-inflammatory cytokines, and of lipoxin A4 and heat shock proteins as mediators of cytokines. We believe that if inflammaging is a key to understand aging, anti-inflammaging may be one of the secrets of longevity.
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Abbreviations
- IL:
-
Interleukin
- NK:
-
Natural killer cells
- TNF:
-
Tumor necrosis factor
- IFN:
-
Interferon
- IL-18BP:
-
IL-18 binding protein
- SNPs:
-
Single nucleotide polymorphisms
- IL-1Ra:
-
IL-1 receptor antagonist
- Hsp:
-
Heat shock proteins
- LX:
-
Lipoxin
- TGF:
-
Transforming growth factor
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Minciullo, P.L., Catalano, A., Mandraffino, G. et al. Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity. Arch. Immunol. Ther. Exp. 64, 111–126 (2016). https://doi.org/10.1007/s00005-015-0377-3
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DOI: https://doi.org/10.1007/s00005-015-0377-3