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Insights into Myeloid-Derived Suppressor Cells in Inflammatory Diseases

  • Review
  • Published:
Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells involved in immune regulation. This population subdivides into granulocytic MDSCs and monocytic MDSCs, which regulate immune responses via the production of various molecules including reactive oxygen species, nitric oxide, arginase-1, interleukin-10, and transforming growth factor-β. Most studies of MDSCs focused on their role in tumors. MDSCs protect tumor cells from immune responses, and thus the frequency of MDSCs associates with poor prognosis. Many recent studies reported an important role for MDSCs in inflammatory diseases via the regulation of immune cells. In addition, the utilization of MDSCs by infectious pathogens suggests an immune evasion mechanism. Thus, MDSCs are important immune regulators in inflammatory diseases, as well as in tumors. This review focuses on the role of MDSCs in the regulation of inflammation in non-tumor settings.

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Acknowledgments

This work was supported by grants from the Korean Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (Grant numbers: HI11C1791 and HI14C1466).

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    1. School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, 500-712, Republic of Korea

      Yewon Kwak, Hye-Eun Kim & Sung Gyoo Park

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    1. Yewon Kwak
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    2. Hye-Eun Kim
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    3. Sung Gyoo Park
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    Correspondence to Sung Gyoo Park.

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    Y. Kwak and H.-E. Kim contributed equally to this work.

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    Kwak, Y., Kim, HE. & Park, S.G. Insights into Myeloid-Derived Suppressor Cells in Inflammatory Diseases. Arch. Immunol. Ther. Exp. 63, 269–285 (2015). https://doi.org/10.1007/s00005-015-0342-1

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