Abstract
In this study, we wanted to examine the effect of magnesium (Mg2+) supplementation on the experimental 3-methyl cholantrene (3-MC)-induced fibrosarcoma and alterations in (Mg2+) distribution in several tissues of the rats, during carcinogenesis. It was determined that serum and tissue (Mg2+) levels of the rats in (Mg2+)-supplemented diet group were higher than those of the rats in the (Mg2+)-nonsupplemented and control groups. The mean time of fibrosarcoma development for (Mg2+)-supplemented group was longer than (Mg2+)-nonsupplemented group (p<0.05). Symptoms of hypermagnesemia were not observed in any of the rats. These results suggests that dietary (Mg2+) supplementation may have a partial anticarcinogenic effect on experimental 3-MC-induced fibrosarcoma by prolongation of the latent period of carcinogenesis.
Similar content being viewed by others
References
B. M. Altura, Importance of magnesium measurements in clinical medicine and therapeutics: Introduction to workshop and symposium,Magnesium Trace Element 10, 5–9 (1991).
B. M. Altura, Basic biochemistry and physiology of magnesium: A brief review,Magnesium, Trace Element 10, 167–171 (1991).
M. Bara, A. G. Bara, and J. Durlach, Magnesium and electrical properties of membranes, inMagnesium in Cellular Processes and Medicine, B. M. Altuna, J. Durlach, and M. S. Seeling (eds.), Karger, Basel, pp 106–120 (1987).
J. Durlach, M. Bara, A. G. Bara, et al., Relationship between magnesium cancer and carcinogenic or anticancer metals,Anticancer Res. 6, 1353–1362 (1986).
G. M. Hass, R. M. Galt, and G. H. Laing, Induction of rat T cell lymphoma-leukemia by magnesium deficiency-A study of fetal defense against maternal neoplasia,Magnesium 8, 45–55 (1989).
P. A. McCreary, H. A. Battifora, and B. M. Hahneman, Leukocytosis, bone marrow hyperplasia and leukemia in choronic magnesium deficiency in the rat,Blood 29, 683–690 (1967).
R. Gossrau, J. Vormann, and T. Günther, Enzyme histochemistry of malignant T cell lymphoma due to chronic magnesium deficiency in rats,Histochemistry 80, 183–186 (1984).
B. J. Mills, W. L. Broghamer, P. J. Higgins, et al., Inhibition of tumor growth by magnesium depletion of rats,J. Nutr. 114, 739–745 (1984).
G. A. Young and F. M. Parsons, The effects of dietary deficiencies of magnesium and potassium on the growth and chemistry of transplanted tumours and host tissues in the rat,Eur. J. Cancer 13, 103–113 (1977).
V. Digiesi, R. Bandinelli, P. Bisceglie, et al., Magnesium in tumoral tissues, in the muscle and serum of subjects suffering from neoplasia,Biochem. Med. 29, 360–363 (1983).
T. Durlach, Summary of three recent magnesium meetings,Magnesium 6, 274–280 (1987).
Z. Szmeja and H. Konezewska, Der Magnesiumgehalt bei larynxpråkanzerosen und larynxkarzinomen,HNO 34, 85–87 (1986).
S. L. Rizk and H. H. Sky-Peck, Comparison between concentrations of trace elements in normal and neoplastic human breast tissue,Cancer Res. 44, 5390–5394 (1984).
J. K. Brennan, A. Lichtman, J. K. Chamberlain, and P. Leblond, Isolation of variant lymphoma cells with reduced growth requirements for extracellular calcium and magnesium and enhanced oncogenicit,Blood 47, 447–459 (1976).
J. T. Bradbury, W. E. Bachmann, and M. G. Lewisohn, The production of cancer by some new chemical compound,Cancer Res. 10, 685–694 (1941).
P. Bois, E. B. Sandborn, and P. E. Messier, A study of thymic lymphosarcoma developing in magnesium-deficient rats,Cancer Res. 29, 763–775 (1969).
L. A. Poirier, K. S. Kasprzak, K. L. Hoover, et al., Effects of calcium and magnesium acetates on the carcinogenecity of cadmium choloride in wistar rats,Cancer Res. 43, 4575–4581 (1983).
L. A. Poirier, J. C. Theiss, L. J. Arnold, et al., Inhibition by magnesium and calcium acetates of lead subacetate and nickel acetate induced lung tumors in strain a mice,Cancer Res. 44, 1520–1522 (1984).
A. W. Horton and B. T. Denial, Carcinogenesis of the skin. A new examination of methods for quantitive measurement of the potencies of complex material,Cancer Res. 15, 701–709 (1956).
M. Diez, M. Arroyo, F. J. Cerdan, et al., Serum and tissue metal levels in lung cancer,Oncology 46, 230–234 (1989).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Patiroğlu, T., Şahin, G., Kontaş, O. et al. Protective effect of magnesium supplementation on experimental 3-methyl cholantrene-induced fibrosarcoma and changes in tissue magnesium distribution during carcinogenesis in rats. Biol Trace Elem Res 56, 179–185 (1997). https://doi.org/10.1007/BF02785391
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02785391