Abstract
The design and application of an interstitial light delivery system suitable for photodynamic therapy of liver metastases is presented. The device incorporates an optical portion and a localization portion. Accurate geometric positioning of four 200 μm diameter optical fibres can be achieved and orientated within a metastasis after initial placement of a single fibre using real time ultrasound imaging. The device can either be applied using the percutaneous route or directly into the liver at laparotomy.
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References
Masters A, Steger AC, Bown SG. Role of interstitial therapy in the treatment of liver cancer.Br J Surg 1991,78:518–23
Steger AC, Lees WR, Walmsley K, Bown SG. Interstitial laser hyperthermia: a new approach to local destruction of tumours.Br Med J 1989,299:362–5
Purkiss SF, Dean R, Williams NS. Interstitial photodynamic therapy for colorectal liver metastases.Br J Surg 1992,79:448
Steger AC, Lees WR, Shorvon P et al. Multiple-fibre low power interstitial laser hyperthermia: studies in normal liver.Br J Surg 1992,79:139–45
Davis M, Dowden J, Steger A et al. A mathematical model for interstitial laser treatment of tumours using four fibres.Lasers Med Sci 1989,4: 41–53
Bolin FP, Preuss LE, Taylor RC. Optimization of photodynamic therapy light dose distribution and treatment volume by multi-fibre insertions.Photochem Photobiol. 1987,46:609–17
Barr H, Krazner N, Boulos PB et al. Photodynamic therapy for colorectal cancer: a quantitative pilot study.Br J Surg 1990,77:93–6
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Purkiss, S.F., Dean, R., Allardice, J.T. et al. An interstitial light delivery system for photodynamic therapy within the liver. Laser Med Sci 8, 253–257 (1993). https://doi.org/10.1007/BF02547848
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DOI: https://doi.org/10.1007/BF02547848