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False positive pleural biopsy and high CA125 levels in serum and pleural effusion in systemic lupus erythematosus

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Summary

A 23-year-old female with systemic lupus erythematosus is reported. The clinical features included fever, shortness of breath, lymphadenopathies, hepatosplenomegaly, pleural and pericardial fluids, ANA and Anti-DNA positivity. Pleural biopsy was false positive for malignancy on two occasions. High CA125 levels were detected in both serum and pleural fluid. Following prednisolone treatment, clinical and laboratory findings returned to normal.

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References

  1. Tan, E.M., Cohen, A.S., Fries, J.F., Masi, A.T., McShane, D.J., Rothfield, N.F., Schaller, J.G., Talal, N., Winchester, R.J. 1982 reviewed criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982, 25, 1271–1277.

    PubMed  Google Scholar 

  2. Miller, L.R., Greenberg, D., Mclarty, J.W. Lupus lung. Chest 1985, 88, 265–269.

    PubMed  Google Scholar 

  3. Pines, A., Kaplinsky, N., Olchovsky, D., Ozeman, J., Frankl, O. Pleura-pulmonary manifestations of systemic lupus erythematosus: clinical features of its subgroups prognostic and therapeutic implications. Chest 1985, 88, 129–135.

    PubMed  Google Scholar 

  4. Lewis, R.B., Castor, C.W., Knisley, R.E., Bole, G.G. Frequency of neoplasia in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum 1976, 19, 1256–1260.

    PubMed  Google Scholar 

  5. Cash, J.M., Klippel, J.H. Rheumatic diseases and cancer. Clin Exp Rheum 1991, 9, 109–112.

    Google Scholar 

  6. Nance, K.V., Shermer, R.W., Askin, F.B. Diagnostic efficacy of pleural biopsy as compared with that of pleural fluid examination. Modern Pathology 1991, 4, 320–324.

    PubMed  Google Scholar 

  7. Hoff, D.D.V., Livolsi, V. Diagnostic reliability of needle biopsy of the pleura. Am J Clin Pathol 1975, 64, 200–203.

    PubMed  Google Scholar 

  8. Poe, R.H., Israel, R.H., Utell, M.J., Hall, W.J., Greenblatt, D.W., Kallay, M.C. Sensitivity, specificity and predictive values of closed pleural biopsy. Arch Intern Med 1984, 144, 325–328.

    Article  PubMed  Google Scholar 

  9. Kelley, S., McGarry, P., Hutson, Y. Atypical cells in pleural fluid of systemic lupus erythematosus. Acta Cytol 1971, 15, 357–362.

    PubMed  Google Scholar 

  10. Bast, R.C., Klug, T.L., John, E.S., Jenison, E., Nloff, J.M., Lazarus, H. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N Engl J Med 1983, 309, 883–887.

    PubMed  Google Scholar 

  11. Macri, C.I., Vasilev, S.A. Highly elevated CA125 and tubo-ovarian abscess mimicking ovarian carcinoma. Gynecol Obstet Invest 1994, 37, 143–144.

    PubMed  Google Scholar 

  12. Ye, C., Ito, K., Komatsu, Y., Takagi, H. Extremely high levels of CA19-9 and CA125 antigen in benign mucinous ovarian cystadenoma. Gynecol Oncol 1994, 52, 267–271.

    Article  PubMed  Google Scholar 

  13. Penna, L., Manyonda, I., Amias, A. Intra-abdominal miliary tuberculosis presenting as disseminated ovarian carcinoma with ascites and raised CA125. Br J Obstet Gynaecol 1993, 100, 1051–1053.

    PubMed  Google Scholar 

  14. Daoud, E., Bodor, G., Weaver, C., Daoud, F., Ladenson, J.H., Scott, M.G. Washington University case conference: CA 125 concentrations in malignant and nonmalignant diseases. Clin Chem 1991, 37, 1968–1974.

    PubMed  Google Scholar 

  15. Soper, J.T., Hunter, V.J., Daly, L., Tannar, M., Creasmen, W.T., Bast, R.C. Preoperative serum tumor-associated antigen levels in women with pelvic masses. Obstet Gynecol 1990, 75, 249–54.

    PubMed  Google Scholar 

  16. Moncayo, R., Moncayo, H. Serum levels of CA 125 are elevated in patients with active systemic lupus erythematosus. Obstet Gynecol 1991, 77, 932–934.

    PubMed  Google Scholar 

  17. Nouwen, E.J., Pollet, D.E., Eerdekens, M.W., Hendrix, P.G., Briers, T.W., De Broe, M.E. Immunohistochemical localization of placental alkaline phosphatase, carcinoembryonic antigen and cancer antigen 125 in normal and neoplastic human lung. Cancer Res 1986, 46, 866–876.

    PubMed  Google Scholar 

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Yucel, A.E., Çalguneri, M. & Ruacan, Ş. False positive pleural biopsy and high CA125 levels in serum and pleural effusion in systemic lupus erythematosus. Clin Rheumatol 15, 197–199 (1996). https://doi.org/10.1007/BF02230341

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  • DOI: https://doi.org/10.1007/BF02230341

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