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Osteoporosis in rheumatoid arthritis: Effect of disease activity

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Summary

In addition to juxtaarticular osteoporosis, which appears to reflect predominantly local disease mechanisms, more generalized bone loss can occur in rheumatoid arthritis(RA). The aim of this study was to compare bone mineral density (BMD) of the lumbar spine and proximal femur in RA patients versus controls and evaluate the influence of disease related determinants. Twenty-seven patients with RA and twenty healthy subjects were included in this study. BMD was significantly reduced in RA patients compared with the control group. BMD was correlated with duration of disease, health assessment questionnaire scores, hand grip strength and erythrocyte sedimentation rate. These results support the hypothesis that BMD may be affected by RA related determinants.

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Authors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Hacettepe University, School of Medicine, 06100, Ankara, Turkey

    R. Çeliker M.D., Y. Gökçe-Kutsal, A. Cindas & O. Basgöze

  2. Department of Radiology, Hacettepe University, School of Medicine, 06100, Ankara, Turkey

    M. Ariyurek

  3. Department of Biochemistry, Hacettepe University, School of Medicine, 06100, Ankara, Turkey

    N. Renda

  4. Department of Nuclear Medicine, Hacettepe University, School of Medicine, 06100, Ankara, Turkey

    Z. Koray

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  1. R. Çeliker M.D.
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  2. Y. Gökçe-Kutsal
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  3. A. Cindas
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  4. M. Ariyurek
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Çeliker, R., Gökçe-Kutsal, Y., Cindas, A. et al. Osteoporosis in rheumatoid arthritis: Effect of disease activity. Clin Rheumatol 14, 429–433 (1995). https://doi.org/10.1007/BF02207677

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  • DOI: https://doi.org/10.1007/BF02207677

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