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Calcium channel blockers prevent stress-induced ulcers in rats

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Abstract

Gastric mucosal damaged induced by cold and restraint stress caused increase in gastric lipid peroxidation (LP) and decrease in gastric glutathione levels. Two calcium-channel blockers, verapamil and nicardipine, prevented stress-induced increase in gastric LP, as well as ulcer formation. Both calcium-channel blockers protected against stress-induced ulcers, and inhibition of LP may be among their mechanisms of action.

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Authors and Affiliations

  1. Department of Biochemistry, Marmara University, School of Medicine, 81326, Haydarpasa, Istanbul, Turkey

    A. Süha Yalçin

  2. Department of Pharmacology, Marmara University, School of Medicine, 81326, Haydarpasa, Istanbul, Turkey

    Sule Oktay

  3. Department of Physiology, Marmara University, School of Medicine, 81326, Haydarpasa, Istanbul, Turkey

    Berrak Ç. Yegen & Inci Alican

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  1. Berrak Ç. Yegen
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  2. Inci Alican
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  3. A. Süha Yalçin
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  4. Sule Oktay
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In memory of Dr. Ilker Aykaç whom we have started with.

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Yegen, B.Ç., Alican, I., Süha Yalçin, A. et al. Calcium channel blockers prevent stress-induced ulcers in rats. Agents and Actions 35, 130–134 (1992). https://doi.org/10.1007/BF01990962

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