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The inclusion complex of piromidic acid with dimethyl-β-cyclodextrin in aqueous solution and in the solid state

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Abstract

Inclusion complex formation of piromidic acid (PA) with dimethyl-β-cyclodextrin (DM-β-CD) in aqueous solution and in the solid state was confirmed by the solubility method, differential scanning calorimetry (DSC) and proton nuclear magnetic resonance (1H-NMR) spectroscopy. The apparent stability constant,K c , of the complex was estimated to be 244 M−1. The stoichiometry of the complex was given as the ratio 1:2 of PA to DM-β-CD. The dissolution rate of the PA/DM-β-CD complex was much greater than that of intact PA.

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, Etiler, Ankara, Turkey

    Nevin Çelebi

  2. Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hoshi University, Ebara, 2-4-41, Shinagawa-ku, 142, Tokyo, Japan

    Osamu Shirakura, Yoshiharu Machida & Tsuneji Nagai

Authors
  1. Nevin Çelebi
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  2. Osamu Shirakura
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  3. Yoshiharu Machida
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  4. Tsuneji Nagai
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Çelebi, N., Shirakura, O., Machida, Y. et al. The inclusion complex of piromidic acid with dimethyl-β-cyclodextrin in aqueous solution and in the solid state. Journal of Inclusion Phenomena 5, 407–413 (1987). https://doi.org/10.1007/BF00664095

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  • DOI: https://doi.org/10.1007/BF00664095

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