Summary
A probe detecting a hypervariable region (HVR) 3′ to the alpha globin locus on chromosome 16 has been used to produce DNA fingerprints. Segregation analysis has revealed multiple, randomly dispersed DNA fragments inherited in a Mendelian fashion with minimal allelism and linkage. The fingerprints are highly polymorphic (probability of chance association between random individuals «10-14). The probe is, therefore, a powerful discriminating tool: it is envisaged that this probe will have forensic applications, including paternity cases, and will be informative in linkage analysis.
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Fowler, S.J., Gill, P., Werrett, D.J. et al. Individual specific DNA fingerprints from a hypervariable region probe: alpha-globin 3′HVR. Hum Genet 79, 142–146 (1988). https://doi.org/10.1007/BF00280553
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DOI: https://doi.org/10.1007/BF00280553