Abstract
Background
Discovering how certain health factors contribute to functional declines may help to promote successful aging.
Aims
To determine the independent and joint associations of handgrip strength (HGS) and cognitive function with instrumental activities of daily living (IADL) and activities of daily living (ADL) disability decline in aging Americans.
Methods
Data from 18,391 adults aged 50 years and over who participated in at least one wave of the 2006–2014 waves of the Health and Retirement Study were analyzed. A hand-held dynamometer assessed HGS and cognitive functioning was examined with a modified version of the Telephone Interview of Cognitive Status. IADL and ADL abilities were self-reported. Participants were stratified into four distinct groups based on their HGS and cognitive function status. Separate covariate-adjusted multilevel models were conducted for the analyses.
Results
Participants who were weak, had a cognitive impairment, and had both weakness and a cognitive impairment had 1.70 (95% confidence interval (CI) 1.57–1.84), 1.97 (CI 1.74–2.23), and 3.13 (CI 2.73–3.59) greater odds for IADL disability decline, respectively, and 2.26 (CI 2.03–2.51), 1.26 (CI 1.05–1.51), and 4.48 (CI 3.72–5.39) greater odds for ADL disability decline, respectively.
Discussion
HGS and cognitive functioning were independently and jointly associated with IADL and ADL disability declines. Individuals with both weakness and cognitive impairment demonstrated substantially higher odds for functional decline than those with either risk factor alone.
Conclusions
Including measures of both HGS and cognitive functioning in routine geriatric assessments may help to identify those at greatest risk for declining functional capacity.
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References
McGrath RP, Kraemer WJ, Al Snih S et al (2018) Handgrip strength and health in aging adults. Sports Med 48:1993–2000
Carson RG (2018) Get a grip: individual variations in grip strength are a marker of brain health. Neurobiol Aging 71:189–222
Clark BC (2018) Neuromuscular changes with aging and sarcopenia. J Frailty Aging 8:7–9
Ohtsuki T (1981) Inhibition of individual fingers during grip strength exertion. Ergonomics 24:21–36
Firth J, Stubbs B, Vancampfort D et al (2018) Grip strength is associated with cognitive performance in schizophrenia and the general population: a UK biobank study of 476559 participants. Schizophr Bull 44:728–736
McGrath R, Robinson-Lane SG, Cook S et al (2019) Handgrip strength is associated with poorer cognitive functioning in aging americans. J Alzheimers Dis 70:1187–1196
Duchowny K (2019) Do nationally representative cutpoints for clinical muscle weakness predict mortality? Results from 9 years of follow-up in the health and retirement study. J Gerontol A Biol Sci Med Sci 74:1070–1075
Shavelle RM, Paculdo DR, Strauss DJ et al (2009) Cognitive impairment and mortality in the Cardiovascular Health Study. J Insur Med 41:110–116
Liang Y, Welmer A-K, Möller J et al (2017) Trends in disability of instrumental activities of daily living among older Chinese adults, 1997–2006: population based study. BMJ Open 7:e016996
Mlinac ME, Feng MC (2016) Assessment of activities of daily living, self-care, and independence. Arch Clin Neuropsychol 31:506–516
South-Paul J, Matheny S, Lewis E (2010) Current diagnosis & treatment in family medicine, 4th edn. McGraw Hill, New York
Gobbens RJ (2018) Associations of ADL and IADL disability with physical and mental dimensions of quality of life in people aged 75 years and older. Peer J 6:e5425
McGrath RP, Clark BC, Erlandson KM et al (2018) Impairments in individual autonomous living tasks and time to self-care disability in middle-aged and older adults. J Am Med Dir Assoc (ppi:1525-8610(18)30587-5)
McGrath RP, Vincent BM, Lee I-M et al (2018) Handgrip strength, function, and mortality in older adults: a time-varying approach. Med Sci Sports Exerc 50:2259–2266
McGrath R, Robinson-Lane SG, Peterson MD et al (2018) Muscle strength and functional limitations: preserving function in older Mexican Americans. J Am Med Dir Assoc 19:391–398
Orellano E, Colón WI, Arbesman MJ (2012) Effect of occupation-and activity-based interventions on instrumental activities of daily living performance among community-dwelling older adults: a systematic review. Am J Occup Ther 66:292–300
Health and Retirement Study (2019) HRS data products. https://hrs.isr.umich.edu/data-products. Accessed 16 Jun 2019
Sonnega A, Faul JD, Ofstedal MB et al (2014) Cohort profile: the health and retirement study (HRS). Int J Epidemiol 43:576–585
Health and Retirement Study (2019) HRS data book. https://hrs.isr.umich.edu/about/data-book?_ga=2.177450149.1489958521.1509473800-353572931.1501594459. Accessed 16 Jun 2019
Plassman BL, Newman TT, Welsh KA et al (1994) Application in epidemiological and longitudinal studies. Cogn Behav Neurol 7:235–241
Crimmins EM, Kim JK, Langa KM et al (2011) Assessment of cognition using surveys and neuropsychological assessment: the health and retirement study and the aging, demographics, and memory study. J Gerontol B Psychol Sci Soc Sci 66:i162–i171
Langa KM, Larson EB, Karlawish JH et al (2008) Trends in the prevalence and mortality of cognitive impairment in the United States: is there evidence of a compression of cognitive morbidity? Alzheimers Dement. 4:134–144
Duchowny KA, Peterson MD, Clarke PJ (2017) Cut points for clinical muscle weakness among older Americans. Am J Prev Med 53:63–69
HRS Documentation Report (2019) Documentation of physical measures, anthropometrics and blood pressure in the health and retirement study. https://hrs.isr.umich.edu/sites/default/files/biblio/dr-011.pdf. Accessed 16 Jun 2019
Turvey CL, Wallace RB, Herzog R (1999) A revised CES-D measure of depressive symptoms and a DSM-based measure of major depressive episodes in the elderly. Int Psychogeriatr 11:139–148
Rosanbalm S (2019) Getting Sankey with bar charts. Getting Sankey with bar charts. https://www.pharmasug.org/proceedings/2015/DV/PharmaSUG-2015-DV07.pdf. Accessed 16 Jun 2019
Liu C-J, Jones LY, Formyduval AR et al (2016) Task-oriented exercise to reduce activities of daily living disability in vulnerable older adults: a feasibility study of the 3-step workout for life. J Aging Phys Act. 24:384–392
Giebel CM, Sutcliffe C, Challis D (2015) Activities of daily living and quality of life across different stages of dementia: a UK study. Aging Ment Health. 19:63–71
Liu C-J, Shiroy DM, Jones LY et al (2014) Systematic review of functional training on muscle strength, physical functioning, and activities of daily living in older adults. Eur Rev Aging Phys Act. 11:95
Blankevoort CG, Van Heuvelen MJ, Boersma F et al (2010) Review of effects of physical activity on strength, balance, mobility and ADL performance in elderly subjects with dementia. Dement Geriatr Cogn Disord 30:392–402
Funding
RMs effort on this research was partially funded by the College of Human Sciences and Education at North Dakota State University. The authors would like to thank those who anecdotally contributed to this research (TMM).
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BCC has received research funding or consulting fees from the NIH, Regeneron Pharmaceuticals, Astellas Pharma Global Development, RTI Health Solutions, Osteopathic Heritage Foundations, Regeneron Pharmaceuticals, Abbott Laboratories, and the Gerson Lehrman Group. Additionally, BCC is co-founder with equity, and serves as the Chief of Aging Research for AEIOU Scientific. The other authors declare no conflicts of interest.
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McGrath, R., Vincent, B.M., Hackney, K.J. et al. Weakness and cognitive impairment are independently and jointly associated with functional decline in aging Americans. Aging Clin Exp Res 32, 1723–1730 (2020). https://doi.org/10.1007/s40520-019-01351-y
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DOI: https://doi.org/10.1007/s40520-019-01351-y