Abstract
Policies regarding cannabis use are rapidly changing, yet public officials have limited access to scientific information that might inform the creation of these policies. One important area in which to begin investigations is the link between recreational cannabis use and health, specifically exercise. There are common anecdotal reports that cannabis decreases motivation, including motivation to exercise. On the other hand, there are also anecdotal reports that cannabis is used prior to athletic activity. In fact, the World Anti-Doping Agency includes cannabis as a prohibited substance in sport, partly because it is believed that it may enhance sports performance. At the current time, there is limited scientific evidence to support either one of these opposing lay perspectives. Given recent political, cultural, and legal trends, and the growing acceptance of recreational cannabis use, it is important to develop a more nuanced understanding of the relationship between cannabis and exercise, specifically the potential effects of use on exercise performance, motivation, and recovery.
References
Hanson K. State medical marijuana laws. National Conference of State Legislatures. 2014. http://www.ncsl.org/research/health/statemedical-marijuana-laws.aspx. Accessed 20 Nov 2014.
Swift A. For first time, Americans favor legalizing marijuana. Gallup. 2013. Available at: http://www.gallup.com/poll/165539/first-time-americans-favor-legalizing-marijuana.aspx. Accessed 5 Nov 2014.
Pew Research Center. 2014. America’s changing drug policy landscape. Available at: http://www.people-press.org/files/legacy-pdf/04-02-14%20Drug%20Policy%20Release.pdf. Accessed 28 May 2014.
Le Strat Y, Le Foll B. Obesity and cannabis use: results from 2 representative national surveys. Am J Epidemiol. 2011;174(8):929–33.
Kozela E, Juknat A, Kaushansky N, Rimmerman N, Ben-Nun A, Vogel Z. Cannabinoids decrease the Th17 inflammatory autoimmune phenotype. J Neuroimmune Pharmacol. 2013;8(5):1265–76.
Huestis MA, Mazzoni I, Rabin O. Cannabis in sport. Sports Med. 2011;41(11):949–66.
Ramaekers JG, Kauert G, van Ruitenbeek P, Theunissen EL, Schneider E, Moeller MR. High-potency marijuana impairs executive function and inhibitory motor control. Neuropsychopharmacology. 2006;31(10):2296–303.
Kvalseth TO. Effects of marijuana on human reaction time and motor control. Percept Mot Skills. 1977;45(3):935–9.
National College Athletic Association (NCAA). National study of substance use trends among NCAA college student-athletes. 2012. Available at: http://www.ncaapublications.com/productdownloads/SAHS09.pdf. Accessed 29 May 2014.
Lorente FO, Peretti-Watel P, Grelot L. Cannabis use to enhance sportive and non-sportive performances among French sport students. Addict Behav. 2005;30(7):1382–91.
Pillard F, Cances-Lauwers V, Godeau E, Navarro F, Rolland Y, Riviere D. Sport practice and cannabis consumption in a representative sample of French high school adolescents [in French]. Ann Med Interne (Paris). 2001;152:28–36.
Tashkin DP, Soares JR, Hepler RS, Shapiro BJ, Rachelefsky GS. Cannabis, 1977. Ann Intern Med. 1978;89(4):539–49.
Pesta DH, Angadi SS, Burtscher M, Roberts CK. The effects of caffeine, nicotine, ethanol, and tetrahydrocannabinol on exercise performance. Nutr Metab. 2013;10:71.
Saugy M, Avois L, Saudan C, Robinson N, Giroud C, Mangin P, et al. Cannabis and sport. Br J Sports Med. 2006;40(Suppl 1):i13–5.
Steadward RD, Singh M. The effects of smoking marihuana on physical performance. Med Sci Sports. 1974;7(4):309–11.
Renaud AM, Cormier Y. Acute effects of marihuana smoking on maximal exercise performance. Med Sci Sports Exerc. 1986;18(6):685–9.
National Institute on Drug Abuse. Marijuana. Available at: http://www.drugabuse.gov/publications/drugfacts/marijuana. Accessed 7 Nov 2014.
Bird KD, Boleyn T, Chesher GB, Jackson DM, Starmer GA, Teo RK. Intercannabinoid and cannabinoid-ethanol interactions on human performance. Psychopharmacology (Berl). 1980;71:181–8.
Ménétrey A, Augsburger M, Favrat B, Pin MA, Rothuizen LE, Appenzeller M, et al. Assessment of driving capability through the use of clinical and psychomotor tests in relation to blood cannabinoids levels following oral administration of 20 mg dronabinol or of a cannabis decoction made with 20 or 60 mg Δ9-THC. J Anal Toxicol. 2005;29(5):327–38.
Favrat B, Menetrey A, Augsburger M, et al. Two cases of “cannabis acute psychosis” following the administration of oral cannabis. BMC Psychiatry. 2005;5:17.
Baden DA, Warwick-Evans L, Lakomy J. Am I nearly there? The effect of anticipated running distance on perceived exertion and attentional focus. J Sport Exerc Psychol. 2004;26(2):215–31.
Potteiger JA, Schroeder JM, Goff KL. Influence of music on ratings of perceived exertion during 20 minutes of moderate intensity exercise. Percept Mot Skills. 2000;91(3):848–54.
Wiles JD, Bird SR, Hopkins J, Riley M. Effect of caffeinated coffee on running speed, respiratory factors, blood lactate and perceived exertion during 1500-m treadmill running. Br J Sports Med. 1992;26(2):116–20.
O’Leary DS, Block RI, Turner BM, Koeppel J, Magnotta VA, Ponto LB, et al. Marijuana alters the human cerebellar clock. Neuroreport. 2003;14(8):1145–51.
Vina J, Sanchis-Gomar F, Martinez-Bello V, Gomez-Cabrera MC. Exercise acts as a drug; the pharmacological benefits of exercise. Br J Pharmacol. 2012;167(1):1–12.
Morris M, Steinberg H, Sykes EA, Salmon P. Effects of temporary withdrawal from regular running. J Psychosom Res. 1990;34(5):493–500.
Dietrich A, McDaniel WF. Endocannabinoids and exercise. Br J Sports Med. 2004;38(5):536–41.
Dishman RK, O’Connor PJ. Lessons in exercise neurobiology: the case of endorphins. Mental Health Phys Act. 2009;2(1):4–9.
Ashton CH, Moore PB. Endocannabinoid system dysfunction in mood and related disorders. Acta Psychiatr Scand. 2011;124(4):250–61.
Sparling PB, Giuffrida A, Piomelli D, Rosskopf L, Dietrich A. Exercise activates the endocannabinoid system. Neuroreport. 2003;14(17):2209–11.
Keeney BK, Raichlen DA, Meek TH, Wijeratne RS, Middleton KM, Gerdeman GL, et al. Differential response to a selective cannabinoid receptor antagonist (SR141716: rimonabant) in female mice from lines selectively bred for high voluntary wheel-running behaviour. Behav Pharmacol. 2008;19(8):812–20.
Keeney BK, Meek TH, Middleton KM, Holness LF, Garland T Jr. Sex differences in cannabinoid receptor-1 (CB1) pharmacology in mice selectively bred for high voluntary wheel-running behavior. Pharmacol Biochem Behav. 2012;101(4):528–37.
Dubreucq S, Durand A, Matias I, Bénard G, Richard E, Soria-Gomez E, et al. Ventral tegmental area cannabinoid type-1 receptors control voluntary exercise performance. Biol Psychiatry. 2013;73(9):895–903.
Fuss J, Gass P. Endocannabinoids and voluntary activity in mice: runner’s high and long-term consequences in emotional behaviors. Exp Neurol. 2010;224(1):103–5.
Garland T, Schutz H, Chappell MA, Keeney BK, Meek TH, Copes LE, Eisenmann JC. The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives. J Exp Biol. 2011;214(2):206–29.
Heyman E, Gamelin FX, Goekint M, Piscitelli F, Roelands B, Leclair E, et al. Intense exercise increases circulating endocannabinoid and BDNF levels in humans—possible implications for reward and depression. Psychoneuroendocrinology. 2012;37(6):844–51.
Brené S, Bjørnebekk A, Åberg E, Mathé AA, Olson L, Werme M. Running is rewarding and antidepressive. Physiol Behav. 2007;92(1):136–40.
Duman CH, Schlesinger L, Russell DS, Duman RS. Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice. Brain Res. 2008;1199:148–58.
Hill MN, Titterness AK, Morrish AC, Carrier EJ, Lee TT, Gil-Mohapel J, et al. Endogenous cannabinoid signaling is required for voluntary exercise-induced enhancement of progenitor cell proliferation in the hippocampus. Hippocampus. 2010;20(4):513–23.
Cheer JF, Wassum KM, Sombers LA, Heien ML, Ariansen JL, Aragona BJ, et al. Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation. J Neurosci. 2007;27(4):791–5.
Maldonado R, Valverde O, Berrendero F. Involvement of the endocannabinoid system in drug addiction. Trends Neurosci. 2006;29(4):225–32.
Dannecker EA, Koltyn KF. Pain during and within hours after exercise in healthy adults. Sports Med. 2014;44(7):921–42.
Pedersen BK. Exercise and cytokines. Immunol Cell Biol. 2000;78(5):532–5.
Scott JP, Sale C, Greeves JP, Casey A, Dutton J, Fraser WD. Effect of exercise intensity on the cytokine response to an acute bout of running. Med Sci Sports Exerc. 2011;43(12):2297–306.
Gleeson M. Immune function in sport and exercise. J Appl Physiol. 2007;103(2):693–9.
Petersen AMW, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol. 2005;98(4):1154–62.
Lewis PB, Ruby D, Bush-Joseph CA. Muscle soreness and delayed-onset muscle soreness. Clin Sports Med. 2012;31(2):255–62.
Dishman RK. Compliance/adherence in health-related exercise. Health Psychol. 1982;1(3):237.
Dannecker EA, Sluka KA. Pressure and activity-related allodynia in delayed-onset muscle pain. Clin J Pain. 2011;27(1):42.
Borgelt LM, Franson KL, Nussbaum AM, Wang GS. The pharmacologic and clinical effects of medical cannabis. Pharmacotherapy. 2013;33(2):195–209.
Klein TW. Cannabinoid-based drugs as anti-inflammatory therapeutics. Nat Rev Immunol. 2005;5(5):400–11.
Baldwin GC, Tashkin DP, Buckley DM, Park AN, Dubinett SM, Roth MD. Marijuana and cocaine impair alveolar macrophage function and cytokine production. Am J Respir Crit Care Med. 1997;156(5):1606–13.
Keen L 2nd, Pereira D, Latimer W. Self-reported lifetime marijuana use and interleukin-6 levels in middle-aged African Americans. Drug Alcohol Depend. 2014;140:156–60.
Machida M, Takemasa T. Ibuprofen administration during endurance training cancels running-distance-dependent adaptations of skeletal muscle in mice. J Physiol Pharmacol. 2010;61(5):559.
Peterson JM, Trappe TA, Mylona E, White F, Lambert CP, Evans WJ, et al. Ibuprofen and acetaminophen: effect on muscle inflammation after eccentric exercise. Med Sci Sports Exerc. 2003;35(6):892–6.
Trappe TA, White F, Lambert CP, Cesar D, Hellerstein M, Evans WJ. Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis. Am J Physiol Endocrinol Metab. 2002;282(3):E551–6.
Izzo AA, Borrelli F, Capasso R, Di Marzo V, Mechoulam R. Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci. 2009;30(10):515–27.
Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011;163(7):1344–64.
Huestis MA. Human cannabinoid pharmacokinetics. Chem Biodivers. 2007;4(8):1770–804.
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Arielle S. Gillman, Kent Hutchison, and Angela Bryan declare they have no conflicts of interest. The authors thank the anonymous reviewers for their helpful comments. No financial support was received for the preparation of this manuscript.
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Gillman, A.S., Hutchison, K.E. & Bryan, A.D. Cannabis and Exercise Science: A Commentary on Existing Studies and Suggestions for Future Directions. Sports Med 45, 1357–1363 (2015). https://doi.org/10.1007/s40279-015-0362-3
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DOI: https://doi.org/10.1007/s40279-015-0362-3