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Rapid and staggered release of small hydrophobic drugs using a micro-organogel embedded film

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Abstract

We designed a biocompatible carrier prepared by ultrasonication of vegetable oils in a protein aqueous solution for controlled dual release of hydrophobic drugs. Tetracycline as antibiotics was encapsulated into micro-organogels that were embedded into PAA matrix with flurbiprofen anti-inflammatory agents. Due to high affinity of PAA to water, flurbiprofen in PAA matrix could rapidly diffuse out from the film, while tetracycline was slowly released from the micro-organogels owing to thermo-responsive rigid core, providing selective staggered dual release of drugs.

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References

  1. Rasenack, N. & Müller, B. W. Dissolution rate enhancement by in situ micronization of poorly water-soluble drugs. Pharm. Res. 19, 1894–1900 (2002).

    Article  CAS  PubMed  Google Scholar 

  2. Allen, T. M. & Cullis, P. R. Drug delivery systems: entering the mainstream. Science 303, 1818–1822 (2004).

    Article  CAS  PubMed  Google Scholar 

  3. Hansch, C., Björkroth, J. & Leo, A. Hydrophobicity and central nervous system agents: on the principle of minimal hydrophobicity in drug design. J. Pharm. Sci. 76, 663–687 (1987).

    Article  CAS  PubMed  Google Scholar 

  4. Wischke, C. & Schwendeman, S. P. Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles. Int. J. Pharm. 364, 298–327 (2008).

    Article  CAS  PubMed  Google Scholar 

  5. Hsu, B. B., Park, M. H., Hagerman, S. R. & Hammond, P. T. Multimonth controlled small molecule release from biodegradable thin films. Proc. Natl. Acad. Sci. U. S. A. 111, 12175–12180 (2014).

    Article  CAS  PubMed  Google Scholar 

  6. Broughton, G., Janis, J. E. & Attinger, C. E. The basic science of wound healing. Plast. Reconstr. Surg. 117, 12S–34S (2006).

    Article  CAS  PubMed  Google Scholar 

  7. Boateng, J. S., Matthews, K. H., Stevens, H. N. E. & Eccleston, G. M. Wound healing dressings and drug delivery systems: A review. J. Pharm. Sci. 97, 2892–2923 (2008).

    Article  CAS  PubMed  Google Scholar 

  8. Cevc, G. & Vierl, U. Nanotechnology and the transdermal route A state of the art review and critical appraisal. J. Control. Release 141, 277–299 (2010).

    Article  CAS  PubMed  Google Scholar 

  9. Park, M. H., Agasti, S. S., Creran, B., Kim, C. & Rotello, V. M. Controlled and Sustained Release of Drugs from Dendrimer-Nanoparticle Composite Films. Adv. Mater. 23, 2839–2842 (2011).

    Article  CAS  PubMed  Google Scholar 

  10. Park, M. H. et al. Replenishable dendrimer-nanoparticle hybrid membranes for sustained release of therapeutics. Nanoscale 5, 7805–7808 (2013).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Ryu, J. H. et al. Self-Cross-Linked Polymer Nanogels: A Versatile Nanoscopic Drug Delivery Platform. J. Am. Chem. Soc. 132, 17227–17235 (2010).

    Article  CAS  PubMed  Google Scholar 

  12. Wasan, K. M., Brocks, D. R., Lee, S. D., Sachs-Barrable, K. & Thornton, S. J. Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery. Nat. Rev. Drug Discov. 7, 84–99 (2008).

    Article  CAS  PubMed  Google Scholar 

  13. Carmona-Ribeiro, A. M. Biomimetic nanoparticles: preparation, characterization and biomedical applications. Int. J. Nanomed. 5, 249–259 (2010).

    Article  CAS  Google Scholar 

  14. Xu, Q. G., Tanaka, Y. & Czernuszka, J. T. Encapsulation and release of a hydrophobic drug from hydroxyapatite coated liposomes. Biomaterials 28, 2687–2694 (2007).

    Article  CAS  PubMed  Google Scholar 

  15. Shubhra, Q. T. H., Toth, J., Gyenis, J. & Feczko, T. Poloxamers for surface modification of hydrophobic drug carriers and their effects on drug delivery. Polym. Rev. 54, 112–138 (2014).

    Article  CAS  Google Scholar 

  16. Aryal, S., Prabaharan, M., Pilla, S. & Gong, S. Biodegradable and biocompatible multi-arm star amphiphilic block copolymer as a carrier for hydrophobic drug delivery. Int. J. Biol. Macromol. 44, 346–352 (2009).

    Article  CAS  PubMed  Google Scholar 

  17. Sahoo, S. et al. Organogels: Properties and Applications in Drug Delivery. Des. Monomers Polym. 14, 95–108 (2011).

    Article  CAS  Google Scholar 

  18. Vintiloiu, A. & Leroux, J. C. Organogels and their use in drug delivery- A review. J. Control. Release 125, 179–192 (2008).

    Article  CAS  PubMed  Google Scholar 

  19. Orlu, M., Cevher, E. & Araman, A. Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. Int. J. Pharm. 318, 103–117 (2006).

    Article  CAS  PubMed  Google Scholar 

  20. Sapadin, A. N. & Fleischmajer, R. Tetracyclines: Nonantibiotic properties and their clinical implications. J. Am. Acad. Dermatol. 54, 258–265 (2006).

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, Sahmyook University, Seoul, 139-742, Korea

    Honglual Park, Soojung Yang & Myoung-Hwan Park

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  1. Honglual Park
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  2. Soojung Yang
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  3. Myoung-Hwan Park
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Correspondence to Myoung-Hwan Park.

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Park, H., Yang, S. & Park, MH. Rapid and staggered release of small hydrophobic drugs using a micro-organogel embedded film. Toxicol. Environ. Health Sci. 6, 238–243 (2014). https://doi.org/10.1007/s13530-014-0211-z

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  • DOI: https://doi.org/10.1007/s13530-014-0211-z

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