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Perspective: Cooperation of Nanog, NF-κΒ, and CXCR4 in a regulatory network for directed migration of cancer stem cells

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Tumor Biology

Abstract

Directed cell migration is a crucial mobility phase of cancer stem cells having stemness and tumorigenic characteristics. It is known that CXCR4 plays key roles in the perception of chemotactic gradients throughout the directed migration of CSCs. There are a number of complex signaling pathways and transcription factors that coordinate with CXCR4/CXCL12 axis during directed migration. In this review, we focus on some transcription factors such as Nanog, NF-κB, and Bmi-1 that cooperate with CXCR4/CXCL12 for the maintenance of stemness and induction of metastasis behavior in cancer stem cells.

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Acknowledgments

The research work in the laboratory of H.D. is supported by grant number 3/25064 from Ferdowsi University of Mashhad, Mashhad, Iran, and grant number 100311 from Council for Stem Cell Sciences and Technologies of Iran and the Research Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran.

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  1. Division of Biotechnology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran

    Masoumeh Es-haghi & Hesam Dehghani

  2. Department of Biology, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran

    Sara Soltanian

  3. Embryonic and Stem Cell Biology and Biotechnology Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran

    Hesam Dehghani

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  1. Masoumeh Es-haghi
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Es-haghi, M., Soltanian, S. & Dehghani, H. Perspective: Cooperation of Nanog, NF-κΒ, and CXCR4 in a regulatory network for directed migration of cancer stem cells. Tumor Biol. 37, 1559–1565 (2016). https://doi.org/10.1007/s13277-015-4690-6

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