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Multifunctional Nanomaterial-alginate Drug Delivery and Imaging System for Cancer Therapy

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Abstract

Although chemotherapy is mostly performed by direct injection of the chemotherapeutic agents systemically, this approach can cause undesirable side effects in normal tissues and lacks targeting efficiency. In this study, we have developed a micron-sized, bead-type multifunctional anticancer-drug carrier that can be injected in the vicinity of a lesion using a syringe. The multifunctional anticancer-drug carrier bead was fabricated by incorporating functional nanomaterials, such as near-infrared (NIR)-responsive gold nanorod (GNR) and superparamagnetic iron oxide nanoparticles (IONP) that work as a magnetic resonance imaging (MRI) contrast agent, into an alginate hydrogel bead. The carrier bead containing GNR and IONP was spherical, with an average size of 362.2 ± 22.7 µm. These multifunctional anticancer-drug carrier beads could successfully release doxorubicin (Dox) into the external environment upon irradiation with an NIR laser. The laser responsive on-demand release profile demonstrated well-controlled and sustained release of Dox, and the effectiveness of this drug delivery system can be confirmed in vitro by the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay. Additionally, the control experiments evidenced that the thermal effect of GNR was insignificant and the cytotoxic action of Dox was expressed only after irradiation with the NIR laser. The multifunctional anticancer-drug carrier beads can be precisely monitored with the MRI T2 imaging mode.

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Acknowledgements

This research was supported by GRRC program of Gyeonggi Province (Grant No. GRRC Sungkyunkwan 2017-A01). S. Moon and Y Park are supported by Gyeonggi Science High School R&E fund. K.H.H. appreciate the support from the Research Fellowship Program (NRF-2018R1A6A3A 11047269). The manuscript was written through the contributions of all authors.

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Authors and Affiliations

  1. SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University (SKKU), Suwon, 16419, Korea

    Seokyoung Yoon, Kwon Hoon Han & Jung Heon Lee

  2. School of Advanced Materials Science and Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Korea

    Junhyuck Chang, Nayoung Kwon, Byungkwon Lim & Jung Heon Lee

  3. Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University (SKKU), Suwon, 16419, Korea

    Jung Heon Lee

  4. Gyeonggi Science High School for the Gifted, Suwon, 16297, Korea

    Seokhoon Moon & Youngmin Park

Authors
  1. Seokyoung Yoon
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  2. Junhyuck Chang
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  3. Nayoung Kwon
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  4. Seokhoon Moon
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  5. Youngmin Park
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  6. Kwon Hoon Han
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  7. Byungkwon Lim
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  8. Jung Heon Lee
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Corresponding authors

Correspondence to Kwon Hoon Han, Byungkwon Lim or Jung Heon Lee.

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The authors declare no competing financial interests.

These authors contrilbuted equally.

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Yoon, S., Chang, J., Kwon, N. et al. Multifunctional Nanomaterial-alginate Drug Delivery and Imaging System for Cancer Therapy. BioChip J 13, 236–242 (2019). https://doi.org/10.1007/s13206-019-3309-1

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  • DOI: https://doi.org/10.1007/s13206-019-3309-1

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