Skip to main content

Advertisement

Log in

Poised for Success: Implementation of Sound Conditioning Strategies to Promote Endogenous Protective Responses to Stroke in Patients

  • Original Article
  • Published:
Translational Stroke Research Aims and scope Submit manuscript

Abstract

The following perspective represents our summary of questions, ideas, concerns, and recommendations expressed by speakers and discussants at the second Biennial Translational Preconditioning Workshop held in Miami in December 2011.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Mergenthaler P, Dirnagl U. Protective conditioning of the brain: expressway or roadblock? The Journal of Physiology. 2011;589(17):4147–55.

    Article  PubMed  CAS  Google Scholar 

  2. Koch S, Katsnelson M, Dong C, Perez-Pinzon M. Remote ischemic limb preconditioning after subarachnoid hemorrhage. Stroke. 2011;42(5):1387–91.

    Article  PubMed  Google Scholar 

  3. Keep M, Elmer E, Fong K, Csiszar K. Intrathecal cyclosporin prolongs survival of late-stage ALS mice. Brain Res. 2001;894:327.

    Article  PubMed  CAS  Google Scholar 

  4. Zhang Y, Park TS, Gidday JM. Hypoxic preconditioning protects human brain endothelium from ischemic apoptosis by Akt-dependent survivin activation. Americal Journal of Physiology Heart Circulation Physiology. 2007;292(6):H2573–81.

    Article  CAS  Google Scholar 

  5. Behl C, Holsboer F. Oxidative stress in the pathogenesis of Alzheimer’s disease and antioxidant neuroprotection. Fortschritte Der Neurologie-Psychiatrie. 1998;66(3):113–21.

    Article  PubMed  CAS  Google Scholar 

  6. Jensen HA, Loukogeorgakis S, Yannopoulos F, Rimpiläinen E, Petzold A, Tuominen H, et al. Remote ischemic preconditioning protects the brain against injury after hypothermic circulatory arrest/clinical perspective. Circulation. 2011;123(7):714–21.

    Article  PubMed  CAS  Google Scholar 

  7. Lyden PD, Lees KR, Davis SM. Alteplase for acute stroke revisited: the first 10 years. The Lancet Neurology. 2006;5(9):722.

    Article  Google Scholar 

  8. Fisher M, for the Stroke Therapy Academic Industry Roundtable IV. Enhancing the development and approval of acute stroke therapies: stroke therapy academic industry roundtable. Stroke. 2005;36(8):1808–13.

    Article  PubMed  Google Scholar 

  9. Lapchak P, Zhang J, Noble-Haeusslein L. RIGOR guidelines: escalating STAIR and STEPS for effective translational research. Translational Stroke Research. 2012. doi:10.1007/s12975-012-0209-2.

  10. Kitano H, Young J, Cheng J, Wang L, Hurn PD, Murphy SJ. Gender-specific response to isoflurane preconditioning in focal cerebral ischemia. Journal of Cerebral Blood Flow & Metabolism. 2007;27:1377–86.

    Article  CAS  Google Scholar 

  11. Bickler PE, Fahlman CS. Enhanced hypoxic preconditioning by isoflurane: signaling gene expression and requirement of intracellular Ca2+ and inositol triphosphate receptors. Brain Res. 2010;1340(20434434):86–95.

    Article  PubMed  CAS  Google Scholar 

  12. Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, et al. A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 2012;490(7419):187–91.

    Article  PubMed  CAS  Google Scholar 

  13. Lefer DJ, Bolli R. Development of an NIH Consortium for PreclinicAl AssESsment of CARdioprotective Therapies (CAESAR): a paradigm shift in studies of infarct size limitation. Journal of Cardiovascular Pharmacology and Therapeutics. 2011;16(3–4):332–9.

    Article  PubMed  Google Scholar 

  14. Vahlhaus C, Schulz R, Post H, Rose J, Heusch G. Prevention of ischemic preconditioning only by combined inhibition of protein kinase c and protein tyrosine kinase in pigs. Journal of Molecular and Cellular Cardiology. 1998;30(2):197–209.

    Article  PubMed  CAS  Google Scholar 

  15. Hoda MN, Siddiqui S, Herberg S, Periyasamy-Thandavan S, Bhatia K, Hafez SS, et al. Remote ischemic perconditioning is effective alone and in combination with intravenous tissue-type plasminogen activator in murine model of embolic stroke. Stroke. 2012;21:2012.

    Google Scholar 

  16. Nowak TS, Zhao L. Conditioning studies in focal cerebral ischemia: model selection, physiological monitoring, and other methodological issues. Springer Series in Translational Stroke Research. 2013. doi:10.1007/978-1-4419-9695-4_13.

  17. Johnston SC, Johnston SC. Ischemic preconditioning from transient ischemic attacks? Data from the Northern California TIA study. Stroke. 2004;35(11_suppl_1):2680–2.

    Article  PubMed  Google Scholar 

  18. Huang DT, Walden H, Duda D, Schulman BA. Ubiquitin-like protein activation. Oncogene. 2004;23(11):1958–71.

    Article  PubMed  CAS  Google Scholar 

  19. Meller R, Minami M, Cameron JA, Impey S, Chen D, Lan JQ, et al. CREB-mediated Bcl-2 protein expression after ischemic preconditioning. J Cereb Blood Flow Metab. 2005;25:234.

    Article  PubMed  CAS  Google Scholar 

  20. Stenzel-Poore MP, Stevens SL, Xiong Z, Lessov NS, Harrington CA, Mori M, et al. Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states. The Lancet. 2003;362(9389):1028–37.

    Article  CAS  Google Scholar 

  21. McLaughlin BA, Hartnett KA, Erhardt JA, Legos JJ, White RF, Barone FC, et al. Caspase 3 activation is essential for neuroprotection in ischemic preconditioning. Proceedings of the National Academy of Sciences of the United States of America. 2003;100(2):715–20.

    Article  PubMed  CAS  Google Scholar 

  22. Yellon DM, Dana A. The preconditioning phenomenon: a tool for the scientist or a clinical reality? Circ Res. 2000;87(7):543–50.

    Article  PubMed  CAS  Google Scholar 

  23. Gidday JM, B.K. McMahan, Y. Zhu. Long-lasting neuroprotection induced in mouse retina by repeated hypoxic preconditioning. Invest Ophthalmol Vis Sci 2003; (Program #2942).

  24. Kadiiska MB, Gladen BC, Baird DD, Graham LB, Parker CE, Ames BN, et al. Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning. Free Radical Biology and Medicine. 2005;38(6):711–8.

    Article  PubMed  CAS  Google Scholar 

  25. Kadiiska MB, Gladen BC, Baird DD, Germolec D, Graham LB, Parker CE, et al. Biomarkers of oxidative stress study II. Are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radical Biology and Medicine. 2005;38(6):698–710.

    Article  PubMed  CAS  Google Scholar 

  26. Goldemund D, Mikulik R. Reperfusion therapies for acute ischemic stroke. Current Treatment Options in Neurology. 2010;12(2):155–66.

    Article  PubMed  Google Scholar 

  27. Abou-Chebl A. Intra-arterial therapy for acute ischemic stroke. Neurotherapeutics. 2011;8(3):400–13.

    Article  PubMed  CAS  Google Scholar 

  28. Furlan AJ. Clot retrieval for stroke should be restricted to clinical trials no. Stroke. 2010;41(1):194–5.

    Article  PubMed  Google Scholar 

  29. Furie KL, Kasner SE, Adams RJ, Albers GW, Bush RL, Fagan SC, et al. Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack. Stroke. 2011;42(1):227–76.

    Article  PubMed  Google Scholar 

  30. Della Morte D, Abete P, Gallucci F, Scaglione A, D'Ambrosio D, Gargiulo G, et al. Transient ischemic attack before nonlacunar ischemic stroke in the elderly. Journal of Stroke and Cerebrovascular Diseases. 2008;17(5):257–62.

    Article  PubMed  Google Scholar 

  31. Dirnagl U, Simon RP, Hallenbeck JM. Ischemic tolerance and endogenous neuroprotection. Trends Neurosci. 2003;26(5):248–54.

    Article  PubMed  CAS  Google Scholar 

  32. Moncayo J, de Freitas GR, Bogousslavsky J, Altieri M, van Melle G. Do transient ischemic attacks have a neuroprotective effect? Neurology. 2000;54(11):2089–94.

    Article  PubMed  CAS  Google Scholar 

  33. McLaughlin BA, Kirshner H. Wagging the dog-moving closer to features defined by basic scientists, the protection of prodromal transient ischaemic attacks reveals itself. European Journal Of Neurology. 2008;15(8):755–6.

    Article  PubMed  CAS  Google Scholar 

  34. O'Duffy AE, Bordelon YM, McLaughlin B. Killer proteases and little strokes-how the things that do not kill you make you stronger. Journal of Cerebral Blood Flow and Metabolism. 2007;27(4):655–68.

    PubMed  Google Scholar 

  35. Weih M, Kallenberg K, Bergk A, Dirnagl U, Harms L, Wernecke KD, Kallenberg K, Bergk A, Dirnagl U, Harms L, Wernecke KD, et al. Attenuated stroke severity after prodromal TIA: a role for ischemic tolerance in the brain? Stroke. 1999;30(9):1851–4.

    Article  PubMed  CAS  Google Scholar 

  36. Wegener S, Gottschalk B, Jovanovic V, Knab R, Fiebach JB, Schellinger PD, et al. Transient ischemic attacks before ischemic stroke: preconditioning the human brain? A multicenter magnetic resonance imaging study. Stroke. 2004;35(3):616–21.

    Article  PubMed  Google Scholar 

  37. Kissela BM, Khoury J, Alwell K, Miller R, Ewing I, Kleindorfer D, Kissela BM, Khoury J, Alwell K, Miller R, Ewing I, Kleindorfer D, et al. Long term mortality after ischemic stroke: the effect of diabetes in the greater Cincinnati/Northern Kentucky Stroke Study (GCNKSS). Stroke. 2004;35(1):315.

    Google Scholar 

  38. Meyer JS, Xu G, Thornby J, Chowdhury MH, Quach M. Is mild cognitive impairment prodromal for vascular dementia like Alzheimer’s disease? Stroke. 2002;33(8):1981–5.

    Article  PubMed  Google Scholar 

  39. Sutherland BA, Minnerup J, Balami JS, Arba F, Buchan AM, Kleinschnitz C. Neuroprotection for ischaemic stroke: translation from the bench to the bedside. International Journal of Stroke. 2012;7(5):407–18.

    Article  PubMed  Google Scholar 

  40. Gonzalez NR, Liebeskind DS. Letter by Gonzalez and Liebeskind regarding article, “Remote ischemic limb preconditioning after subarachnoid hemorrhage: a Phase Ib study of safety and feasibility”. Stroke. 2011;42(9):e553.

    Google Scholar 

  41. Meng R, Asmaro K, Meng L, Liu Y, Ma C, Xi C, et al. Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis. Neurology. 2012;79(18):1853–61.

    Article  PubMed  Google Scholar 

  42. Davies SS, Traustadóttir T, Stock AA, Ye F, Shyr Y, Harman SM, et al. Ischemia/reperfusion unveils impaired capacity of older adults to restrain oxidative insult. Free Radical Biology and Medicine. 2009;47(7):1014–8.

    Article  PubMed  CAS  Google Scholar 

  43. Zaugg M, Lucchinetti E, Uecker M, Pasch T, Schaub MC. Anaesthetics and cardiac preconditioning. Part I. Signalling and cytoprotective mechanisms. Br J Anaesth. 2003;91(4):551–65.

    Article  PubMed  CAS  Google Scholar 

  44. de Leciñana MA, Fuentes B, Masjuan J, Simal P, Díaz-Otero F, Reig G, et al. Thrombolytic therapy for acute ischemic stroke after recent transient ischemic attack. International Journal of Stroke. 2012;7(3):213–8.

    PubMed  Google Scholar 

  45. Veighey K, MacAllister RJ. Clinical applications of remote ischemic preconditioning. Cardiology Research and Practice. 2012;2012:9.

    Article  Google Scholar 

  46. Thuny F, Lairez O, Roubille F, Mewton N, Rioufol G, Sportouch C, et al. Post-conditioning reduces infarct size and edema in patients with ST-segment elevation myocardial infarction. Journal of the American College of Cardiology. 2012;59(24):2175–81.

    Article  PubMed  Google Scholar 

  47. Thibault H, Piot C, Staat P, Bontemps L, Sportouch C, Rioufol G, et al. Long-term benefit of postconditioning. Circulation. 2008;117(8):1037–44.

    Article  PubMed  CAS  Google Scholar 

  48. Botker HE, Kharbanda R, Schmidt MR, Bottcher M, Kaltoft AK, Terkelsen CJ, et al. Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial. Lancet. 2010;375(20189026):727–34.

    Article  PubMed  Google Scholar 

  49. Ludman AJ, Yellon DM, Hausenloy DJ. Cardiac preconditioning for ischaemia: lost in translation. Dis Model Mech. 2010;3(1–2):35–8.

    Article  PubMed  Google Scholar 

Download references

Conflict of Interest Statement

The authors declare that they have no conflicts of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to BethAnn McLaughlin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

McLaughlin, B., Gidday, J.M. Poised for Success: Implementation of Sound Conditioning Strategies to Promote Endogenous Protective Responses to Stroke in Patients. Transl. Stroke Res. 4, 104–113 (2013). https://doi.org/10.1007/s12975-012-0240-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12975-012-0240-3

Keywords

Navigation