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Neuroprotective effects of constituents of Eragrostis ferruginea against Aβ-induced toxicity in PC12 cells

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Abstract

A new flavonoid, 7-demethylageconyflavone A (1), and five known compounds, tricin (2), ageconyflavone A (3), corylin (4), nectandrin B (5), and 4-ketopinoresinol (6) were isolated from the aerial parts of Eragrostis ferruginea. Their structures were determined using spectroscopic techniques, including 1D- and 2D-NMR. All compounds were tested for the neuroprotective effects against amyloid beta peptide (Aβ) using PC12 cells, a major cause of the pathology of Alzheimer’s disease. Tricin (2) was found to have a neuroprotective effect with an ED50 value of 20.3 μM against Aβ-induced toxicity in PC12 cells. Ageconyflavone A (3), nectandrin B (5) and 4-ketopinoresinol (6) demonstrated moderate neuroprotective effects with ED50 values of 58.7, 44.1, and 54.8 μM, respectively.

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Correspondence to Dongho Lee.

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Na, C.S., Hong, S.S., Choi, YH. et al. Neuroprotective effects of constituents of Eragrostis ferruginea against Aβ-induced toxicity in PC12 cells. Arch. Pharm. Res. 33, 999–1003 (2010). https://doi.org/10.1007/s12272-010-0704-5

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  • DOI: https://doi.org/10.1007/s12272-010-0704-5

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