Abstract
This study investigated the 70% aqueous acetone extract of the fruits of Schisandra rubriflora which led to the isolation of eight lignans, including a new isolate, rubrisandrin C (1), and seven known lignans (2–8). The structure of 1 was established by extensive 1D and 2D NMR spectroscopy and its absolute stereochemistry was determined by CD spectrum. Compounds 1–5 and 7–8 were evaluated for their anti-HIV-1 activity that showed inhibitory activity on HIV-1IIIB induced syncytium formation with EC50 values in the range of 2.26∼20.4 μg/mL. Compounds 1 and 7 exerted their obvious protection of HIV-1IIIB inducted MT-4 host cells lytic effects with a selectivity index of 15.4 and 24.6, respectively.
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Xiao, WL., Wang, RR., Zhao, W. et al. Anti-HIV-1 activity of lignans from the fruits of Schisandra rubriflora . Arch. Pharm. Res. 33, 697–701 (2010). https://doi.org/10.1007/s12272-010-0508-7
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DOI: https://doi.org/10.1007/s12272-010-0508-7