Abstract
Natural killer (NK) lymphocytes kill infected and tumorous cells. A balance of stimulatory and inhibitory receptor signals determine their activity. The most important NK cell receptors are the polymorphic killer cell immunoglobulin-like receptors (KIR), which bind to HLA class I molecules on target cells. The enormous genetic and genomic diversity of the KIR/HLA system influences the susceptibility to various diseases. Here, we will give an overview of this system and its impact on HIV infection.
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Beatrix Petersen 2001–2007 Biologiestudium an der Universität Göttingen. 2007–2008 wissenschaft - liche Mitarbeiterin am Deutschen Primatenzentrum, Göttingen. 2008–2012 Promotion, 2012–2013 Postdoc am Institut für Immunologie der Universität Münster. Seit 2015 Postdoc in der Abteilung Primatengenetik am Deutschen Primatenzentrum, Göttingen.
Lutz Walter 1985–1992 Biologiestudium, 1992–1994 Promotion, 1994–1999 wissenschaftlicher Mitarbeiter, 1999–2004 wissenschaftlicher Assistent, 2005 Habilitation im Fach Immunologie und Immungenetik, 2009 apl. Professor an der Universität Göttingen. Seit 2004 Leiter der Abteilung Primatengenetik am Deutschen Primatenzentrum, Göttingen.
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Petersen, B., Walter, L. Genomik des KIR/HLA-Systems und Regulation von NK-Lymphozyten. Biospektrum 22, 600–602 (2016). https://doi.org/10.1007/s12268-016-0736-6
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DOI: https://doi.org/10.1007/s12268-016-0736-6