Skip to main content
Log in

Do it your (path)way –synthetische Wege zur CO2-Fixierung

Stoffwechseldesign

  • Wissenschaft · Methoden
  • Published:
BIOspektrum Aims and scope

Abstract

The sustainable conversion of carbon dioxide into value-added compounds is the key to realize a low-carbon economy. Here we discuss the limitation of natural CO2 fixation pathways, describe a strategy to design and realize efficient pathways for CO2 fixation in bottom-up approaches with synthetic biology, and sketch possible future applications of synthetic CO2 fixation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Literatur

  1. Shih PM, Occhialini A, Cameron JC et al. (2016) Biochemical characterization of predicted Precambrian RuBisCO. Nat Commun 7:10382

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Tcherkez GGB, Farquhar GD, Andrews TJ (2006) Despite slow catalysis and confused substrate specificity, all ribulose bisphosphate carboxylases may be nearly perfectly optimized. Proc Natl Acad Sci USA 103:7246–7251

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Erb TJ, Brecht V, Fuchs G et al. (2009) Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase. Proc Natl Acad Sci USA 106:8871–8876

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Rosenthal RG, Ebert MO, Kiefer P et al. (2014) Direct evidence for a covalent ene adduct intermediate in NAD(P)Hdependent enzymes. Nat Chem Biol 10:50–55

    Article  CAS  PubMed  Google Scholar 

  5. Quade N, Huo LJ, Rachid S et al. (2012) Unusual carbon fixation gives rise to diverse polyketide extender units. Nat Chem Biol 8:117–124

    Article  CAS  Google Scholar 

  6. Peter DM, Schada von Borzyskowski L, Kiefer P et al. (2015) Screening and engineering the synthetic potential of carboxylating reductases from central metabolism and polyketide biosynthesis. Angew Chem 54:13457–13461

    Article  CAS  Google Scholar 

  7. Bar-Even A, Noor E, Lewis NE et al. (2010) Design and analysis of synthetic carbon fixation pathways. Proc Natl Acad Sci USA 107:8889–8894

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Opgenorth PH, Korman TP, Bowie JU (2016) A synthetic biochemistry module for production of bio-based chemicals from glucose. Nat Chem Biol 12:393–395

    Article  CAS  PubMed  Google Scholar 

  9. Linster CL, Noel G, Stroobant V et al. (2011) Ethylmalonyl- CoA decarboxylase, a new enzyme involved in metabolite proofreading. J Biol Chem 286:42992–43003

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tobias J. Erb.

Additional information

Thomas Schwander 2009–2012 Biologiestudium, ETH Zürich, Schweiz. 2012–2014 Mikrobiologiestudium (Master), ETH Zürich. Seit 2014 Promotion am Max-Planck-Institut für terrestrische Mikrobiologie, Marburg.

Tobias J. Erb 1999–2005 Chemie- und Biologiestudium, Universität Freiburg. 2005–2009 Doktorarbeit, Universität Freiburg und Ohio State University, USA. 2009–2011 Postdoc am Institute for Genomic Biology, University of Illinois, USA. 2011–2014 Nachwuchs - gruppenleiter, ETH Zürich, Schweiz. Seit November 2014 Leiter der Gruppe „Bio - chemie und Synthetische Biologie des Mikrobiellen Metabolismus“ am Max-Planck- Institut für terrestrische Mikrobiologie, Marburg.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Schwander, T., Erb, T.J. Do it your (path)way –synthetische Wege zur CO2-Fixierung. Biospektrum 22, 590–592 (2016). https://doi.org/10.1007/s12268-016-0733-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12268-016-0733-9

Navigation