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Study of bantam miRNA expression in brain tumour resulted due to loss of polarity modules in Drosophila melanogaster

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Abstract

Disturbance of delicate concordance between stem cell proliferation, specification and differentiation during brain development leads to several neural disorders including tumours. Accumulating evidences have demonstrated involvement of short noncoding microRNAs (miRNAs) in governing several biological as well as pathological processes, including tumourigenesis across various species. Drosophila bantam miRNA, known to regulate critical physiological functions is reported to have elevated expression in ovarian tumour. Here, we provide an update on the expression of bantam miRNA in Drosophila brain tumour background resulting due to loss of well characterized polarity proteins, Brat, Lgl and Scrib. Since, both miRNA TaqMan assay and bantam sensor assay showed elevated expression of bantam in brain tumour background, it clearly reflects presence of an antagonistic relationship between polarity proteins and bantam miRNA indicating of its involvement in tumour progression.

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Acknowledgements

We thank the fly community for generously providing fly stocks. We duly acknowledge Banaras Hindu University for providing the National facility for Laser Scanning Confocal microscopy and Invitrogen Bio Services, Gurgaon, India and Interdisciplinary School of Life Sciences, Banaras Hindu University for extending thermocycler facility.

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Authors and Affiliations

  1. Banaras Hindu University, Varanasi, 221 005, India

    Animesh Banerjee & Jagat K. Roy

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  1. Animesh Banerjee
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  2. Jagat K. Roy
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Correspondence to Jagat K. Roy.

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Banerjee A. and Roy J. K. 2017 Study of bantam miRNA expression in brain tumour resulted due to loss of polarity modules in Drosophila melanogaster. J. Genet. 96, xx-xx

Corresponding editor: L. S. Shashidhara

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Banerjee, A., Roy, J.K. Study of bantam miRNA expression in brain tumour resulted due to loss of polarity modules in Drosophila melanogaster . J Genet 96, 365–369 (2017). https://doi.org/10.1007/s12041-017-0782-y

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  • DOI: https://doi.org/10.1007/s12041-017-0782-y

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