Abstract
Prostate cancer is rarely associated with leptomeningeal metastasis. An 87-year-old man with a history of prostate cancer presented with leptomeningeal metastasis. He received hormonal therapy with leuprolide. Subsequently, he achieved an impressive response, indicated by a constant fall in his PSA levels and by the stabilization of leptomeningeal disease and clinical improvement. Hormonal therapy may be effective in inducing remission in hormone-sensitive prostate cancer with leptomeningeal metastasis.
References
Kesari S, Batchelor TT. Leptomeningeal metastases. Neurol Clin. 2003 Feb;21(1):25–66.
Chamberlain MC. Leptomeningeal metastases: a review of evaluation and treatment. J Neurooncol. 1998 May;37(3):271–84.
Benjamin R. Neurologic complications of prostate cancer. Am Fam Physician. 2002;65(9):1834–40.
Orphanos G, Ardavanis A. Leptomeningeal metastases from prostate cancer: an emerging clinical conundrum. Clin Exp Metastasis. 2010;27(1):19–23.
Tremont-Lukats IW, Bobustuc G, Lagos GK, Lolas K, Kyritsis AP, Puduvalli VK. Brain metastasis from prostate carcinoma: The M. D. Anderson Cancer Center experience. Cancer. 2003;98(2):363–8.
Chiang PH, Lee TC, Huang CC. Intracranial metastasis of prostate cancer: report of two cases. Chang Gung Med J. 2004;27(10):770–6.
Hong MK, Kong J, Namdarian B, et al. Paraneoplastic syndromes in prostate cancer. Nat Rev Urol. 2010;7(12):681–92.
Lin C, Turner S, Gurney H, Peduto A. Increased detections of leptomeningeal presentations in men with hormone refractory prostate cancer: an effect of improved systemic therapy? J Med Imaging Radiat Oncol. 2008;52(4):376–81.
Cone LA, Koochek K, Henager HA, et al. Leptomeningeal carcinomatosis in a patient with metastatic prostate cancer: case report and literature review. Surg Neurol. 2006;65(4):372–5, discussion 5–6.
Wasserstrom WR, Glass JP, Posner JB. Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients. Cancer. 1982;49(4):759–72.
Deinsberger R, Regatschnig R, Kaiser B, Bankl HC. Spinal leptomeningeal metastases from prostate cancer. Acta Neurochir (Wien). 2006 Apr;148(4):467–71.
Hentschel SJ, Mendel E, Singh S, Rhines LD. Metastatic prostate carcinoma to the intradural extramedullary spinal compartment. Case report. J Neurosurg. 2004;100(4 Suppl Spine):375–7.
Glantz MJ, Walters BC. Diagnosis and outcome measures in trials for neoplastic meningitis: a review of the literature and clinical experience. Neurosurg Focus. 1998;4(6):e4.
Bokstein F, Lossos A, Siegal T. Leptomeningeal metastases from solid tumors: a comparison of two prospective series treated with and without intra-cerebrospinal fluid chemotherapy. Cancer. 1998;82(9):1756–63.
Sethi R, Sanfilippo N. Six-month depot formulation of leuprorelin acetate in the treatment of prostate cancer. Clin Interv Aging. 2009;4:259–67.
Conflict of interest
None declared.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Zhang, M., Mahta, A., Kim, R.Y. et al. Durable remission of leptomeningeal metastases from hormone-responsive prostate cancer. Med Oncol 29, 806–808 (2012). https://doi.org/10.1007/s12032-011-9906-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12032-011-9906-z