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The influence of Arhgef1 on pulmonary leukocyte function

  • Immunology in Colorado
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Abstract

Resident leukocytes in the lungs of healthy individuals are necessary for the innate and adaptive immune response toward potentially harmful foreign antigens that are inhaled on a constant basis. Under normal circumstances, inflammatory stimuli are effectively eradicated via innate immunity with accompanying resolution of inflammation and repair of the lung tissue. Work in our lab has explored how Arhgef1, an intracellular signaling molecule expressed by hematopoietic cells, participates in immune function with an emphasis on its contribution to pulmonary immunity. This review summarizes our studies on the role of Arhgef1 in regulating pulmonary macrophage function.

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Acknowledgments

This work was supported by a postdoctoral NIAID (T32-AI07045) training Grant (JMH), a FAMRI Young Clinical Scientist Award (JMH), the Herman Dana Trust (RMT) and a National Jewish Health Translational Research Initiative award (RMT).

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Authors and Affiliations

  1. Integrated Department of Immunology, National Jewish Health and University of Colorado Denver, Denver, CO, USA

    Yue Guan, Raul M. Torres & John M. Hartney

  2. Integrated Department of Immunology, National Jewish Health and University of Colorado School of Medicine, 1400 Jackson St., Denver, CO, 80206, USA

    John M. Hartney

Authors
  1. Yue Guan
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  2. Raul M. Torres
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  3. John M. Hartney
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Correspondence to John M. Hartney.

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Guan, Y., Torres, R.M. & Hartney, J.M. The influence of Arhgef1 on pulmonary leukocyte function. Immunol Res 55, 162–166 (2013). https://doi.org/10.1007/s12026-012-8360-0

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  • DOI: https://doi.org/10.1007/s12026-012-8360-0

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