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A new functional role of HIV-1 integrase during uncoating of the viral core

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Abstract

An early and critical event of the human immunodeficiency virus type 1 (HIV-1) life cycle is uncoating of the viral core. Uncoating involves the disassembly of HIV-1 capsid (CA). The underlying mechanisms governing uncoating are poorly defined, and the role of viral and host factors in uncoating is not well understood. Cyclophilin A and TRIM5α are two cellular factors that interact with CA in exerting their effects on HIV-1 replication. Here, we review the current understanding of uncoating and the new functional role of HIV-1 IN during uncoating.

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Acknowledgments

This work was supported by NIH grants CA68859 and AI077386 to S.A.C. and a MARC Predoctoral Fellowship F31GM083356 to M.S.B.

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  1. Department of Molecular and Medical Pharmacology, Molecular Biology Institute, 650 Charles E. Young Dr, CHS 23-133, Los Angeles, CA, 90095, USA

    Marisa S. Briones & Samson A. Chow

  2. UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, CA, 90095, USA

    Marisa S. Briones & Samson A. Chow

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  1. Marisa S. Briones
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  2. Samson A. Chow
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Correspondence to Samson A. Chow.

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Briones, M.S., Chow, S.A. A new functional role of HIV-1 integrase during uncoating of the viral core. Immunol Res 48, 14–26 (2010). https://doi.org/10.1007/s12026-010-8164-z

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  • DOI: https://doi.org/10.1007/s12026-010-8164-z

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