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Neuropeptide Y and gamma-melanocyte stimulating hormone (γ-MSH) share a common pressor mechanism of action

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Abstract

Central circuits known to regulate food intake and energy expenditure also affect central cardiovascular regulation. For example, both the melanocortin and neuropeptide Y (NPY) peptide families, known to regulate food intake, also produce central hypertensive effects. Members of both families share a similar C-terminal amino acid residue sequence, RF(Y) amide, a sequence distinct from that required for melanocortin receptor binding. A recently delineated family of RFamide receptors recognizes both of these C-terminal motifs. We now present evidence that an antagonist with Y1 and RFamide receptor activity, BIBO3304, will attenuate the central cardiovascular effects of both gamma-melanocyte stimulating hormone (γ-MSH) and NPY. The use of synthetic melanocortin and NPY peptide analogs excluded an interaction with melanocortin or Y family receptors. We suggest that the anatomical convergence of NPY and melanocortin neurons on cardiovascular control centers may have pathophysiological implications through a common or similar RFamide receptor(s), much as they converge on other nuclei to coordinately control energy homeostasis.

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Acknowledgments

This research was supported by NIH R01 DK51730 and NIH R01 DK070332 (RDC), NIH RO1 DK62179 (W.F), and Canadian Institutes of Health Research grant MT 10520 (W. F. Colmers). W. F. Colmers is a Medical Scientist of the Alberta Heritage Foundation for Health Research. MJSC was supported by a 75th Anniversary Award from the Faculty of Medicine and Dentistry, University of Alberta. Kenneth A. Gruber was supported by R01 DK51730-S1.

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Authors and Affiliations

  1. The Center for the Study of Weight Regulation and Associated Disorders and The Vollum Institute, Oregon Health and Science University, L481, 3181 SW Sam Jackson Park Road, Portland, OR, 97239-3098, USA

    Kenneth A. Gruber, Wei Fan & Roger D. Cone

  2. Department of Neuroscience, Uppsala University, Uppsala, Sweden

    Helena Akerberg & Dan Larhammar

  3. Department of Pharmacology, University of Alberta, Edmonton, AB, Canada

    Melissa J. S. Chee & William F. Colmers

  4. Department of Molecular Physiology and Biophysics, Vanderbilt University, 702 Light Hall, Nashville, TN, 37232, USA

    Roger D. Cone

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  1. Kenneth A. Gruber
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Correspondence to Roger D. Cone.

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K. A. Gruber—on leave from Department of Biological Sciences, California State Polytechnic University, Pomona, CA, USA.

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Gruber, K.A., Fan, W., Akerberg, H. et al. Neuropeptide Y and gamma-melanocyte stimulating hormone (γ-MSH) share a common pressor mechanism of action. Endocr 35, 312–324 (2009). https://doi.org/10.1007/s12020-008-9141-3

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