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New mechanism for an old drug Aspirin triggers anti-inflammatory lipid mediators with gender implications

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Comprehensive Therapy

Abstract

Aspirin increases anti-inflammatory aspirin-triggered lipoxin A4 levels in healthy subjects in a gender-specific manner in a randomized clinical study. Thus, formation of aspirin-triggered lipoxin A4 may provide a novel mechanism underlying aspirin's clinical benefits, and shed light on gender-dependent therapeutics of aspirin.

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Authors and Affiliations

  1. The Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, 02115, Boston, MA

    Nan Chiang & Charles N. Serhan PhD

Authors
  1. Nan Chiang
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  2. Charles N. Serhan PhD
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Corresponding author

Correspondence to Charles N. Serhan PhD.

Additional information

The authors have stated that they do not have a significant financial interest or other relationship with any product manufacturer or provider of services discussed in this article. The authors do not discuss the use of off-label products, which includes unlabeled, unapproved, or investigative products or devices.

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Chiang, N., Serhan, C.N. New mechanism for an old drug Aspirin triggers anti-inflammatory lipid mediators with gender implications . Compr Ther 32, 150–157 (2006). https://doi.org/10.1007/s12019-006-0005-6

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  • DOI: https://doi.org/10.1007/s12019-006-0005-6

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