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Trace Element Levels in Hashimoto Thyroiditis Patients with Subclinical Hypothyroidism

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Abstract

The present study was conducted to evaluate the serum copper, zinc, magnesium, and selenium levels in patients with subclinical hypothyroidism in the iodine-rich region of Ankara, Turkey. The effects of hormone replacement therapy on these elements were also studied in these patients. Basal levels of selenium and iron in patients were significantly lower than control group (67.7 ± 10.4 vs. 83.7 ± 17.3 μg/dl, p = 0.02; 55.7 ± 38 vs 275.7 ± 24, P = 0.03 μg/dl). Serum magnesium levels were significantly higher in patient group (2.16 ± 0.31 vs 1.95 ± 0.13 mg/dl, P < 0.0001). There was a correlation between selenium levels with hsCRP (r = −0.408, p = 0.007). HsCRP levels in patients with selenium levels <80 μg/l (n = 31) was significantly higher than hsCRP levels in patients with selenium levels >80 μg/l (n = 12; 1.99 ± 1.0; 1.02 ± 0.9, p = 0.014). None of these biochemical risk factors and trace elements have changed after euthyroidism in patients with SH when compared to pretreatment levels. Selenium deficiency may contribute to cardiovascular disease risk in these patients.

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Authors and Affiliations

  1. Department of Family Medicine, Gulhane School of Medicine, Etlik, Ankara, Turkey

    Muhammed Erdal & Kenan Saglam

  2. Department of Endocrinology and Metabolism, Gulhane School of Medicine, Etlik, Ankara, Turkey

    Mustafa Sahin, Gökhan Uckaya & Mustafa Kutlu

  3. Department of Biochemistry, Gulhane School of Medicine, Etlik, Ankara, Turkey

    Adnan Hasimi

  4. Endocrinology and Metabolism Department, Gulhane University School of Medicine, Zulfikar sok 28/8 Buyukesat, Ankara, Turkey

    Mustafa Sahin

Authors
  1. Muhammed Erdal
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  2. Mustafa Sahin
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  3. Adnan Hasimi
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  4. Gökhan Uckaya
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  5. Mustafa Kutlu
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  6. Kenan Saglam
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Correspondence to Mustafa Sahin.

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Erdal, M., Sahin, M., Hasimi, A. et al. Trace Element Levels in Hashimoto Thyroiditis Patients with Subclinical Hypothyroidism. Biol Trace Elem Res 123, 1–7 (2008). https://doi.org/10.1007/s12011-008-8117-8

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  • DOI: https://doi.org/10.1007/s12011-008-8117-8

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