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Aerosol-Assisted Plasma Deposition of Hydrophobic Polycations Makes Surfaces Highly Antimicrobial

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Abstract

The currently used multistep chemical synthesis for making surfaces antimicrobial by attaching to them hydrophobic polycations is replaced herein by an aerosol-assisted plasma deposition procedure. To this end, N,N-hexyl,methyl-PEI (HMPEI) is directly plasma-coated onto a glass surface. The resultant immobilized HMPEI coating has been thoroughly characterized and shown to be robust, bactericidal against Escherichia coli, and virucidal against human influenza virus.

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Acknowledgments

This research was financially supported by the US Army Research Office under contract W911NF-07-D-0004.

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Authors and Affiliations

  1. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA

    Harris Liu & Alexander M. Klibanov

  2. Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA

    Alexander M. Klibanov

  3. Triton Systems, Inc., 200 Turnpike Road, Chelmsford, MA, 01824, USA

    Yoojeong Kim, Kerrianne Mello, Apoorva Shah & Norman Rice

  4. US Army Research Laboratory, Multifunctional Materials Branch, Weapons & Materials Research Directorate, Aberdeen Proving Ground, Aberdeen, MD, 21005-5069, USA

    Jacqueline H. Yim & Daphne Pappas

  5. Triton Systems, Inc., 1854 Research Circle North, Suite 215, Fargo, ND, 58102, USA

    John Lovaasen

Authors
  1. Harris Liu
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  2. Yoojeong Kim
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  3. Kerrianne Mello
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  4. John Lovaasen
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  5. Apoorva Shah
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  6. Norman Rice
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  7. Jacqueline H. Yim
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  8. Daphne Pappas
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  9. Alexander M. Klibanov
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Correspondence to Alexander M. Klibanov.

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Liu, H., Kim, Y., Mello, K. et al. Aerosol-Assisted Plasma Deposition of Hydrophobic Polycations Makes Surfaces Highly Antimicrobial. Appl Biochem Biotechnol 172, 1254–1264 (2014). https://doi.org/10.1007/s12010-013-0593-4

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  • DOI: https://doi.org/10.1007/s12010-013-0593-4

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