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Fibromyalgia and Sleep in Animal Models: A Current Overview and Future Directions

  • Fibromyalgia (M Peres, Section Editor)
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Abstract

Sleep disorders are highly prevalent in patients with fibromyalgia (FM). Many of the daytime symptoms, such as chronic pain and fatigue, may be related to the non-restorative sleep patterns associated with the disease. Pain influences the sleep process and sleep disturbances decrease the pain threshold in a reciprocal framework. Thus, understanding the link between sleep and FM has become an important research topic in basic science. Therefore, in the current review we connect these topics and provide some insights into the cyclic relationship between sleep and pain, which has been addressed mainly in animal models. Additionally, we highlight the urgent need for sleep studies in FM animal models, which might improve the knowledge base and accelerate advances in this field.

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Acknowledgments

Our research was supported by Associação Fundo de Incentivo à Pesquisa (AFIP) and Fundação de Amparo à Pesquisa do Estado de São Paulo (#10/50130-0 to PA). MLA and ST are the recipients of a fellowship from CNPq.

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Conflict of Interest

Cristina Frange, MsC, Camila Hirotsu, PhD, Helena Hachul, PhD, Paula Araujo, PhD, Sergio Tufik, PhD, and Monica L. Andersen, PhD each declare no potential conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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  1. Departamento de Psicobiologia, Universidade Federal de São Paulo, Rua Napoleão de Barros, 925, Vila Clementino, 04024-002, São Paulo, SP, Brazil

    Cristina Frange, Camila Hirotsu, Helena Hachul, Paula Araujo, Sergio Tufik & Monica L. Andersen

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  1. Cristina Frange
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  2. Camila Hirotsu
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  3. Helena Hachul
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  4. Paula Araujo
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  5. Sergio Tufik
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  6. Monica L. Andersen
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Correspondence to Monica L. Andersen.

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This article is part of the Topical Collection on Fibromyalgia

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Frange, C., Hirotsu, C., Hachul, H. et al. Fibromyalgia and Sleep in Animal Models: A Current Overview and Future Directions. Curr Pain Headache Rep 18, 434 (2014). https://doi.org/10.1007/s11916-014-0434-3

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  • DOI: https://doi.org/10.1007/s11916-014-0434-3

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