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Relationship between receptive vocabulary and the neural substrates for story processing in preschoolers

  • SI: Developing Brain
  • Published:
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Abstract

A left-lateralized fronto-temporo-parietal language network has been well-characterized in adults; however, the neural basis of this fundamental network has hardly been explored in the preschool years, despite this being a time for rapid language development and vocabulary growth. We examined the functional imaging correlates associated with vocabulary ability and narrative comprehension in 30 preschool children ages 3 to 5. Bilateral auditory cortex and superior temporal activation as well as left angular and supramarginal gyrus activation were observed during a passive listening-to-stories task. Boys showed greater activation than girls in the right anterior cingulate and right superior frontal gyrus (SFG). Finally, children with higher vocabulary scores showed increased grey matter left-lateralization and greater activation in bilateral thalamus, hippocampus, and left angular gyrus. This study is novel in its approach to relate left-hemisphere language regions and vocabulary scores in preschool-aged children using fMRI.

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Conflict of Interest

M. Claire Sroka, Jennifer Vannest, Thomas C. Maloney, Tzipi Horowitz-Kraus, Anna W. Byars, Scott K. Holland, and the CMIND Authorship Consortium (Holland, Vannest, Schmithorst, Altaye, Lee, Hernandez-Garcia, Wagner, Toga, Levitt, Byars, Dimitrijevic, Felicelli, Kadis, Leach, Peariso, Plante, Rajagopal, Rupert, Schapiro, Ly, Petrosyan, Wang, and Freund declare that they have no conflicts of interest.

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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, and the applicable revisions at the time of the investigation. Informed consent was obtained from all patients for being included in the study.

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Authors and Affiliations

  1. Pediatric Neuroimaging Research Consortium, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave. ML 5033, Cincinnati, OH, 45229, USA

    M. Claire Sroka, Jennifer Vannest, Thomas C. Maloney, Tzipi Horowitz-Kraus, Anna W. Byars & Scott K. Holland

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  1. M. Claire Sroka
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  2. Jennifer Vannest
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  3. Thomas C. Maloney
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  4. Tzipi Horowitz-Kraus
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Correspondence to Jennifer Vannest.

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The CMIND (Cincinnati MR Imaging of NeuroDevelopment) Authorship Consortium

Scott K. Holland, Ph.D.1,6,9,10

Jennifer Vannest, Ph.D.1,5

Vincent J. Schmithorst, Ph.D.1,2

Mekibib Altaye, Ph.D.1,7

Gregory Lee, Ph.D.1,6

Luis Hernandez-Garcia, Ph.D.3

Michael Wagner, Ph.D.1,8

Arthur Toga, Ph.D. 12,13

Jennifer Levitt, MD14

Anna W. Byars, Ph.D1,5

Andrew Dimitrijevic, Ph.D.9,10

Nicolas Felicelli8

Darren Kadis, Ph.D.1,5

James Leach, MD1,6

Katrina Peariso, MD, Ph.D.5

Elena Plante, Ph.D.4

Akila Rajagopal, M.S.1

Andrew Rupert, M.S.8

Mark Schapiro, MD1,5

Ronald Ly14

Petros Petrosyan12

JJ Wang, Ph.D.11

Lisa Freund, Ph.D.15

1Pediatric Neuroimaging Research Consortium

5Div. of Neurology, Dept. of Pediatrics

6Dept. of Radiology

7Div. of Biostatistics and Epidemiology, Dept. of Pediatrics

8Div. of Biomedical Informatics, Dept. of Pediatrics

9Dept. of Otolaryngology

10Communication Sciences Research Center

Cincinnati Children’s Hospital Medical Center

University of Cincinnati

3333 Burnet Ave.

Cincinnati, OH 45229

2Pediatric Imaging Research Center, Dept. of Radiology

Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA

3Functional MRI Laboratory, Dept. of Biomedical Engineering

University of Michigan, Ann Arbor, MI

4Dept. of Speech, Language, and Hearing Sciences

University of Arizona, Tucson, AZ

11Dept. of Neurology, UCLA, Los Angeles, CA

12Laboratory of Neuroimaging, Keck School of Medicine of USC, Los Angeles, CA

13 Departments of Ophthalmology, Neurology, Psychiatry, and the Behavioral Sciences, Radiology and Engineering, Keck School of Medicine of USC, Los Angeles, CA

14 Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA

15 Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD

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Sroka, M.C., Vannest, J., Maloney, T.C. et al. Relationship between receptive vocabulary and the neural substrates for story processing in preschoolers. Brain Imaging and Behavior 9, 43–55 (2015). https://doi.org/10.1007/s11682-014-9342-8

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  • DOI: https://doi.org/10.1007/s11682-014-9342-8

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