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Biomarkers for NeuroAIDS: The Widening Scope of Metabolomics

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Abstract

“Metabolomics”, the measurement of metabolite concentrations and fluxes in cell systems, is an emerging science that has enormous potential and several unique characteristics. The current applications for this field are, primarily, toxicological profiling and biomarker studies. This review of metabolomics research highlights the identification of reliable biomarkers with emphasis on neuroAIDS. Such identification of candidate markers will be advantageous for tracking the progression of human immunodeficiency virus/central nervous system (HIV/CNS) disease to gain maximal benefit from antiretroviral treatment and to provide insight into the mechanism of related neuropathogenesis.

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Acknowledgments

Our work on biomarkers in neuroAIDS is supported by NIH grants MH073490 and MH062261. This is manuscript number 18317 from The Scripps Research Institute.

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Authors and Affiliations

  1. Molecular and Integrative Neurosciences Department, Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA

    Gurudutt Pendyala & Howard S. Fox

  2. Department of Chemistry and Center for Mass Spectrometry, Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA

    Elizabeth J. Want, William Webb & Gary Siuzdak

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  1. Gurudutt Pendyala
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  2. Elizabeth J. Want
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  3. William Webb
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  4. Gary Siuzdak
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  5. Howard S. Fox
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Correspondence to Howard S. Fox.

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Pendyala, G., Want, E.J., Webb, W. et al. Biomarkers for NeuroAIDS: The Widening Scope of Metabolomics. Jrnl Neuroimmune Pharm 2, 72–80 (2007). https://doi.org/10.1007/s11481-006-9041-3

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