Abstract
Research in biology and medicine is a rapidly expanding field incorporating some of the most fundamental questions concerning structure, function, and purpose. The forefront of new research demands access to advanced techniques and instrumentation capable of probing these unanswered questions. Over the past several decades, nano-scale materials and devices ranging from quasi-one dimensional quantum dots to two dimensional graphene sheets have been engineered and have found applications in nano-bio imaging and spectroscopy. In this review, the incorporation of nanomaterials into three influential spectroscopic and microscopic techniques including fluorescence microscopy, surface plasmon resonance, and sum frequency generation will be introduced. Fluorescence imaging has visualized nanomaterials as compliments or replacements to comparable organic fluorphores, act as a quencher for FRET-based sensing, and serve as a nanoscaffold for molecular beacons. Their versatility in coating materials makes nanomaterials an excellent targeting molecule for any cellular macromolecule or structure. In addition to the targeting capabilities of nanomaterials in fluorescence imaging, surface plasmon resonance has incorporated nanomaterials for applications in signal enhancement, selectivity of target molecules, and the development of more refined and accurate detection. Functionalized nanoparticles enhance the capabilities of sum frequency generation vibrational spectroscopy by providing unique surface chemistry which alters target molecule interactions and orientations. In summary, the incorporation of nanomaterials has greatly enhanced the field of biology and medicine and has allowed for the continual advancement of not only research but instrument development.
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Javey A, Guo J, Wang Q, et al. Ballistic carbon nanotube field-effect transistors. Nature, 2003, 424: 654–657
Zhang X X, Liu D F, Zhang L H, et al. Synthesis of large-scale periodic ZnO nanorod arrays and its blue-shift of UV luminescence. J Mater Chem, 2009, 19: 962–969
Huang M H, Mao S, Feick H, et al. Room-temperature ultraviolet nanowire nanolasers. Science, 2001, 292: 1897–1899
Cui Y, Lieber C M. Functional nanoscale electronic devices assembled using silicon nanowire building blocks. Science, 2001, 291: 851–853
Duan X F, Huang Y, Agarwal R, et al. Single-nanowire electrically driven lasers. Nature, 2003, 421: 241–245
Huang Y, Duan X F, Cui Y, et al. Logic gates and computation from assembled nanowire building blocks. Science, 2001, 294: 1313–1317
Li W Z, Xie S S, Qian L X, et al. Large-scale synthesis of aligned carbon nanotubes. Science, 1996, 274: 1701–1703
Yang Y C, Zhang X X, Gao M, et al. Nonvolatile resistive switching in single crystalline ZnO nanowires. Nanoscale, 2011, 3: 1917–1921
Wang S. Fundamentals of Semiconductor Theory and Device Physics. New York: Prentice Hall Englewood Cliffs, 1989
Gaponenko S V. Optical Properties of Semiconductor Nanocrystals. Cambridge: Cambridge University Press, 1998
Erickson H P. Size and shape of protein molecules at the nanometer level determined by sedimentation, gel filtration, and electron microscopy. Biol Proced Online, 2009, 11: 32–51
Dabbousi B, Rodriguez-Viejo J, Mikulec F V, et al. (CdSe)ZnS core-shell quantum dots: Synthesis and characterization of a size series of highly luminescent nanocrystallites. J Phys Chem B, 1997, 101: 9463–9475
Gerion D, Pinaud F, Williams S C, et al. Synthesis and properties of biocompatible water-soluble silica-coated CdSe/ZnS semiconductor quantum dots. J Phys Chem B, 2001, 105: 8861–8871
Masuda H, Satoh M. Fabrication of gold nanodot array using anodic porous alumina as an evaporation mask. Jpn J Appl Phys, 1996, 35: L126–L129
Fuhrmann B, Leipner H S, Höche H. Ordered arrays of silicon nanowiresproduced by nanosphere lithography and molecular beam epitaxy. Nano Lett, 2005, 5: 2524–2527
Liu D F, Xiang Y J, Zhang Z X, et al. Growth of ZnO hexagonal nanoprisms. Nanotechnology, 2005, 16: 2665–2669
Ma D D, Lee C S, Au F C, et al. Small-diameter silicon nanowire surfaces. Science, 2003, 299: 1874–1877
Stankovich S, Dikin D A, Piner R D, et al. Synthesis of graphene-based nanosheets via chemical reduction of exfoliated graphite oxide. Carbon, 2007, 45: 1558–1565
Geim A K, Novoselov K S. The rise of graphene. Nat Mater, 2007, 6: 183–191
Dikin D A, Stankovich S, Zimney E J, et al. Preparation and characterization of graphene oxide paper. Nature, 2007, 448: 457–460
Novoselov K, Geim A, Morozov S, et al. Electric field effect in atomically thin carbon films. Science, 2004, 306: 666–669
Zhang Z X, Yuan H J, Gao Y, et al. Large-scale synthesis and optical behaviors of ZnO tetrapods. Appl Phy Lett, 2007, 90: 1531161–1531163
Dick K A, Deppert K, Larsson M W, et al. Synthesis of branched “nanotrees” by controlled seeding of multiple branching events. Nat Mater, 2004, 3: 380–384
Zhao Y P, Ye D X, Wang G C, et al. Novel nano-column and nano-flower arrays by glancing angle deposition. Nano Lett, 2002, 2: 351–354
Tong Y H, Liu Y C, Shao C L, et al. Structural and optical properties of ZnO nanotower bundles. Appl Phy Lett, 2006, 88: 123111–123113
Chan W C W, Nie S M. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science, 1998, 281: 2016–2018
Medintz I L, Uyeda H T, Goldman E R, et al. Quantum dot bioconjugates for imaging, labelling and sensing. Nat Mater, 2005, 4: 435–446
Han M, Gao X, Su J Z, et al. Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules. Nat Biotechnol, 2001, 19: 631–635
Cui Y, Wei Q Q, Park H K, et al. Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species. Science, 2001, 293: 1289–1292
Li L S, Hu J T, Yang W D, et al. Band gap variation of size-and shape-controlled colloidal CdSe quantum rods. Nano Lett, 2001, 1: 349–351
Byun K M, Kim S J, Kim D. Design study of highly sensitive nanowire-enhanced surface plasmon resonance biosensors using rigorous coupled wave analysis. Opt Express, 2005, 13: 3737–3742
Lou J Y, Tong L M, Ye Z Z. Modeling of silica nanowires for optical sensing. Opt Express, 2005, 13: 2135–2140
Sun X M, Liu Z, Welsher K, et al. Nano-graphene oxide for cellular imaging and drug delivery. Nano Res, 2008, 1: 203–212
Mohanty N, Berry V. Graphene-based single-bacterium resolution biodevice and DNA transistor: Interfacing graphene derivatives with nanoscale and microscale biocomponents. Nano Lett, 2008, 8: 4469–4476
Wang Y, Li Z H, Hu D H, et al. Aptamer/graphene oxide nanocomplex for in situ molecular probing in living cells. J Am Chem Soc, 2010, 132: 9274–9276
Shan C, Yang H, Song J, et al. Direct electrochemistry of glucose oxidase and biosensing for glucose based on graphene. Anal Chem, 2009, 81: 2378–2382
Yang P D, Yan R X, Fardy M. Semiconductor nanowire: What’s next? Nano Lett, 2010, 10: 1529–1536
Allen B L, Kichambare P D, Star A. Carbon nanotube field-effect-transistor-based biosensors. Adv Mater, 2007, 19: 1439–1451
Patolsky F, Zheng G, Lieber C M. Nanowire-based biosensors. Anal Chem, 2006, 78: 4260–4269
Kapuscinski J. DAPI: A DMA-specific fluorescent probe. Biotech Histochem, 1995, 70: 220–233
James T W, Jope C. Visualization by fluorescence of chloroplast DNA in higher plants by means of the DNA-specific probe 4′6-diamidino-2-phenylindole. J Cell Biol, 1978, 79: 623–630
Latt S A, Stetten G, Juergens L A, et al. Recent developments in the detection of deoxyribonucleic acid synthesis by 33258 Hoechst fluorescence. J Histochem Cytochem, 1975, 23: 493–505
Latt S, Stetten G. Spectral studies on 33258 Hoechst and related bisbenzimidazole dyes useful for fluorescent detection of deoxyri-bonucleic acid synthesis. J Histochem Cytochem, 1976, 24: 24–33
Liedberg B, Nylander C, Lunstrom I. Surface plasmon resonance for gas detection and biosensing. Sens Actuator, 1983, 4: 299–304
Homola J, Yee S S, Gauglitz G. Surface plasmon resonance sensors: Review. Sens Actuator B-Chem, 1999, 54: 3–15
Jönsson U, Fägerstam L, Ivarsson B, et al. Real-time biospecific interaction analysis using surface plasmon resonance and a sensor chip technology. Biotechniques, 1991, 11: 620–627
Kelly K L, Coronado E, Zhao L L, et al. The optical properties of metal nanoparticles: The influence of size, shape, and dielectric environment. J Phys Chem B, 2003, 107: 668–677
He L, Musick M D, Nicewarner S R, et al. Colloidal Au-enhanced surface plasmon resonance for ultrasensitive detection of DNA hybridization. J Am Chem Soc, 2000, 122: 9071–9077
Yuk J S, Ha K S. Proteomic applications of surface plasmon resonance biosensors: Analysis of protein arrays. Exp Mol Med, 2005, 37: 1–10
Nath N, Chilkoti A. A colorimetric gold nanoparticle sensor to interrogate biomolecular interactions in real time on a surface. Anal Chem, 2002, 74: 504–509
Chah S, Hammond M R, Zare R N. Gold nanoparticles as a colorimetric sensor for protein conformational changes. Chem Biol, 2005, 12: 323–328
Chen Z, Shen Y R, Somorjai G A. Studies of polymer surfaces by sum frequency generation vibrational spectroscopy. Annu Rev Phys Chem, 2002, 53: 437–465
Chen Z. Understanding surfaces and buried interfaces of polymer materials at the molecular level using sum frequency generation vibrational spectroscopy. Polym Int, 2007, 56: 577–587
Chen Z. Investigating buried polymer interfaces using sum frequency generation vibrational spectroscopy. Prog Polym Sci, 2010, 35: 1376–1402
Liu Y W, Jasensky J, Chen Z. Molecularinteractions of proteins and peptides at interfaces studied by sum frequency generation vibrational spectroscopy. Langmuir, 2012, 28: 2113–2121
Ding B, Chen Z. Molecular interactions between cell penetrating peptide pep-1 and model cell membranes. J Phys Chem B, 2012, 116: 2545–2552
Wang J, Lee S H, Chen Z. Quantifying the ordering of adsorbed proteins in situ. J Phys Chem B, 2008, 112: 2281–2290
Wang J, Clarke M L, Zhang Y B, et al. Using isotope-labeled proteins and sum frequency generation vibrational spectroscopy to study protein adsorption. Langmuir, 2003, 19: 7862–7866
Even M A, Wang J, Chen Z. Structural information of mussel adhesive protein Mefp-3 acquired at various polymer/Mefp-3 solution interfaces. Langmuir, 2008, 24: 5795–5801
Le Clair S V, Nguyen K, Chen Z. Sum frequency generation studies on bioadhesion: Elucidating the molecular structure of proteins at interfaces. J Adhes, 2009, 85: 484–511
Nguyen K T, Le Clair S V, Ye S J, et al. Orientation determination of protein helical secondary structures using linear and nonlinear vibrational spectroscopy. J Phys Chem B, 2009, 113: 12169–12180
Wang J, Mark A, Chen X Y, et al. Detection of amide I signals of interfacial proteins in situ using SFG. J Am Chem Soc, 2003, 125: 9914–9915
Ye S J, Nguyen K T, Boughton A P, et al. Orientation difference of chemically immobilized and physically adsorbed biological molecules on polymers detected at the solid/liquid interfaces in situ. Langmuir, 2009, 26: 6471–6477
Ye S J, Nguyen K T, Chen Z. Interactions of alamethicin with model cell membranes investigated using sum frequency generation vibrational spectroscopy in real time in situ. J Phys Chem B, 2010, 114: 3334–3340
Chen X Y, Wang J, Sniadecki J J, et al. Probing α-helical and β-sheet structures of peptides at solid/liquid interfaces with SFG. Langmuir, 2005, 21: 2662–2664
Ye S J, Nguyen K T, Clair S V L, et al. In situ molecular level studies on membrane related peptides and proteins in real time using sum frequency generation vibrational spectroscopy. J Struct Biol, 2009, 168: 61–77
Chen X Y, Boughton A P, Tesmer J J G, et al. In situ investigation of heterotrimeric G protein βγ subunit binding and orientation on membrane bilayers. J J Am Chem Soc, 2007, 129: 12658–12659
Chen X Y, Wang J, Boughton A P, et al. Multiple orientation of melittin inside a single lipid bilayer determined by combined vibrational spectroscopic studies. J Am Chem Soc, 2007, 129: 1420–1427
Nguyen K T, Le Clair S V, Ye S J, et al. Molecular interactions between magainin 2 and model membranes in situ. J Phys Chem B, 2009, 113: 12358–12363
Chen X Y, Chen Z. SFG studies on interactions between antimicrobial peptides and supported lipid bilayers. Biochim Biophys Acta, 2006, 1758: 1257–1273
Nguyen K T, Soong R, Lm S C, et al. Probing the spontaneous membrane insertion of a tail-anchored membrane protein by sum frequency generation spectroscopy. J Am Chem Soc, 2010, 132: 15112–15115
Avery C W, Palermo E F, Mclaughlin A, et al. Investigations of the interactions between synthetic antimicrobial polymers and substrate-supported lipid bilayers using sum frequency generation vibrational spectroscopy. Anal Chem, 2011, 83: 1342–1349
Avery C W, Chen Z. Characterizing the interactions between cell membranes and antimicrobials via sum-frequency generation vibrational spectroscopy. Antimicrobial Polymers, 2011, 429–457
Yang P, Ramamoorthy A, Chen Z. Membrane orientation of msi-78 measured by sum frequency generation vibrational spectroscopy. Langmuir, 2011, 27: 7760–7767
Boughton A P, Yang P, Tesmer V M, et al. Heterotrimeric G protein β1γ2 subunits change orientation upon complex formation with G protein-coupled receptor kinase 2 (GRK2) on a model membrane. Proc Natl Acad Sci USA, 2011, 108: E667–E673
Boughton A P, Nguyen K, Andricioaei I, et al. Interfacial orientation and secondary structure change in tachyplesin i: Molecular dynamics and sum frequency generation spectroscopy studies. Langmuir, 2011, 27: 14343–14351
Asanuma H, Noguchi H, Uosaki K, et al. Metal cation-induced deformation of dna self-assembled monolayers on silicon: Vibrational sum frequency generation spectroscopy. J Am Chem Soc, 2008, 130: 8016–8022
Walter S R, Geiger F M. DNA on stage: Showcasing oligonucleotides at surfaces and interfaces with second harmonic and vibrational sum frequency generation. J Phy Chem Lett, 2009, 1: 9–15
Sartenaer Y, Tourillon G, Dreesen L, et al. Sum-frequency generation spectroscopy of DNA monolayers. Biosens Bioelectron, 2007, 22: 2179–2183
Wang J, Chen X Y, Clarke M L, et al. Detection of chiral sum frequency generation vibrational spectra of proteins and peptides at interfaces in situ. Proc Natl Acad Sci USA, 2005, 102: 4978–4983
Nel A E, Mädler L, Velegol D, et al. Understanding biophysico-chemical interactions at the nano-bio interface. Nat Mater, 2009, 8: 543–557
Lodish H, Berk A, Zipursky S L, et al. Molecular Cell Biology. New York: W.H. Freeman & Company, 1995
Mirkin C A, Letsinger R L, Mucic R C, et al. A DNA-based method for rationally assembling nanoparticles into macroscopic materials. Nature, 1996, 382: 607–609
Parak W J, Pellegrino T, Micheel C M, et al. Conformation of oligonucleotides attached to gold nanocrystals probed by gel electrophoresis. Nano Lett, 2003, 3: 33–36
Hanaki K, Momo A, Oku T, et al. Semiconductor quantum dot/albumin complex is a long-life and highly photostable endosome marker. Biochem Biophys Res Commun, 2003, 302: 496–501
Erlanger B F, Chen B X, Zhu M, et al. Binding of an anti-fullerene IgG monoclonal antibody to single wall carbon nanotubes. Nano Lett, 2001, 1: 465–468
Mahtab R, Harden H H, Murphy C J. Temperature-and salt-dependent binding of long DNA to protein-sized quantum dots: Thermodynamics of “inorganic protein”-DNA interactions. J Am Chem Soc, 2000, 122: 14–17
Mattoussi H, Mauro J M, Goldman E R, et al. Self-assembly of CdSe-ZnS quantum dot bioconjugates using an engineered recombinant protein. J Am Chem Soc, 2000, 122: 12142–12150
Mattoussi H, Mauro J, Goldman E, et al. Bioconjugation of highly luminescent colloidal cdse-zns quantum dots with an engineered two-domain recombinant protein. Phys Status Solidi B, 2001, 224: 277–283
Dubertret B, Skourides P, Norris D J, et al. In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science, 2002, 298: 1759–1762
Wu X Y, Liu H J, Liu J Q, et al. Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nat Biotechnol, 2002, 21: 41–46
Chan W C W, Maxwell D J, Gao X, et al. Luminescent quantum dots for multiplexed biological detection and imaging. Curr Opin Biotechnol, 2002, 13: 40–46
Miyawaki A. Visualization of the spatial and temporal dynamics of intracellular signaling. Dev Cell, 2003, 4: 295–305
Schröck E, Du Manoir S, Veldman T, et al. Multicolor spectral karyotyping of human chromosomes. Science, 1996, 273: 494–497
Leatherdale C, Woo W K, Mikulec F, et al. On the absorption cross section of CdSe nanocrystal quantum dots. J Phys Chem B, 2002, 106: 7619–7622
Shao Y Y, Wang J, Wu H, et al. Graphene based electrochemical sensors and biosensors: A review. Electroanalysis, 2010, 22: 1027–1036
Huang Y X, Dong X C, Shi Y M, et al. Nanoelectronic biosensors based on CVD grown graphene. Nanoscale, 2010, 2: 1485–1488
Bruchez Jr M, Moronne M, Gin P, et al. Semiconductor nanocrystals as fluorescent biological labels. Science, 1998, 281: 2013–2016
Derfus A M, Chan W C W, Bhatia S N. Intracellular delivery of quantum dots for live cell labeling and organelle tracking. Adv Mater, 2004, 16: 961–966
Gao X H, Cui Y Y, Levenson R M, et al. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol, 2004, 22: 969–976
Mahtab R, Rogers J P, Murphy C J. Protein-sized quantum dot luminescence can distinguish between “straight”, “bent”, and “kinked” oligonucleotides. J Am Chem Soc, 1995, 117: 9099–9100
Mahtab R, Rogers J P, Singleton C P, et al. Preferential adsorption of a “kinked” DNA to a neutral curved surface: Comparisons to and implications for nonspecific DNA-protein interactions. J Am Chem Soc, 1996, 118: 7028–7032
Taton T A, Mirkin C A, Letsinger R L. Scanometric DNA array detection with nanoparticle probes. Science, 2000, 289: 1757–1760
Yablonovitch E. Inhibited spontaneous emission in solid-state physics and electronics. Phys Rev Lett, 1987, 58: 2059–2062
Vos W, Polman A. Optical probes inside photonic crystals. MRS Bull, 2001, 26: 642–646
Asher S A, Peteu S F, Reese C E, et al. Polymerized crystalline colloidal array chemical-sensing materials for detection of lead in body fluids. Anal Bioanal Chem, 2002, 373: 632–638
Reese C E, Asher S A. Photonic crystal optrode sensor for detection of Pb2+ in high ionic strength environments. Anal Chem, 2003, 75: 3915–3918
Asher S A, Alexeev V L, Goponenko A V, et al. Photonic crystal carbohydrate sensors: Low ionic strength sugar sensing. J Am Chem Soc, 2003, 125: 3322–3329
Fu A H, Gu W W, Boussert B, et al. Semiconductor quantum rods as single molecule fluorescent biological labels. Nano Lett, 2007, 7: 179–182
Dhar S, Liu Z, Thomale J, et al. Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device. J Am Chem Soc, 2008, 130: 11467–11476
Liu Z, Cai W B, He L, et al. In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. Nat Nanotechnol, 2006, 2: 47–52
Al Faraj A, Cieslar K, Lacroix G, et al. In vivo imaging of carbon nanotube biodistribution using magnetic resonance imaging. Nano Lett, 2009, 9: 1023–1027
Singh R, Pantarotto D, Mccarthy D, et al. Binding and condensation of plasmid DNA onto functionalized carbon nanotubes: Toward the construction of nanotube-based gene delivery vectors. J Am Chem Soc, 2005, 127: 4388–4396
Podesta J E, Al-Jamal K T, Herrero M A, et al. Antitumor activity and prolonged survival by carbon-nanotube-mediated therapeutic sirna silencing in a human lung xenograft model. Small, 2009, 5: 1176–1185
Meng J, Duan J, Kong H, et al. Carbon nanotubes conjugated to tumor lysate protein enhance the efficacy of an antitumor immunotherapy. Small, 2008, 4: 1364–1370
Lin S, Keskar G, Wu Y, et al. Detection of phospholipid-carbon nanotube translocation using fluorescence energy transfer. Appl Phys Lett, 2006, 89: 143111–143118
Didenko V V, Baskin D S. Horseradish peroxidase-driven fluorescent labeling of nanotubes with quantum dots. Biotechniques, 2006, 40: 295–302
Cheng J, Fernando K A S, Veca L M, et al. Reversible accumulation of PEGylated single-walled carbon nanotubes in the mammalian nucleus. ACS Nano, 2008, 2: 2085–2094
Jia F M, Wu L, Meng J, et al. Preparation, characterization and fluorescent imaging of multi-walled carbon nanotube-porphyrin conjugate. J Mater Chem, 2009, 19: 8950–8957
Yang R H, Tang Z W, Yan J L, et al. Noncovalent assembly of carbon nanotubes and single-stranded DNA: An effective sensing platform for probing biomolecular interactions. Anal Chem, 2008, 80: 7408–7413
Yang R H, Jin J Y, Chen Y, et al. Carbon nanotube-quenched fluorescent oligonucleotides: Probes that fluoresce upon hybridization. J Am Chem Soc, 2008, 130: 8351–8358
Lu C H, Yang H H, Zhu C L, et al. A graphene platform for sensing biomolecules. Angew Chem Int Ed, 2009, 48: 4785–4787
He S J, Song B, Li D, et al. A graphene nanoprobe for rapid, sensitive, and multicolor fluorescent DNA analysis. Adv Funct Mater, 2010, 20: 453–459
Jang H, Kim Y K, Kwon H M, et al. A graphene-based platform for the assay of duplex-dna unwinding by helicase. Angew Chem Int Ed, 2010, 122: 5839–5843
Broude N E. Stem-loop oligonucleotides: A robust tool for molecular biology and biotechnology. Trends Biotechnol, 2002, 20: 249–256
Tyagi S, Kramer F R. Molecular beacons: Probes that fluoresce upon hybridization. Nat Biotechnol, 1996, 14: 303–308
Venkatesan N, Seo Y J, Kim B H. Quencher-free molecular beacons: A new strategy in fluorescence based nucleic acid analysis. Chem Soc Rev, 2008, 37: 648–663
Tyagi S, Bratu D P, Kramer F R. Multicolor molecular beacons for allele discrimination. Nat Biotechnol, 1998, 16: 49–53
Song S P, Liang Z Q, Zhang J, et al. Gold-nanoparticle-based multicolor nanobeacons for sequence-specific dna analysis. Angew Chem Int Ed, 2009, 48: 8670–8674
Tang Z W, Wu H, Cort J R, et al. Constraint of DNA on functionalized graphene improves its biostability and specificity. Small, 2010, 6: 1205–1209
Wen Y Q, Xing F F, He S J, et al. A graphene-based fluorescent nanoprobe for silver(I) ions detection by using graphene oxide and a silver-specific oligonucleotide. Chem Commun, 2010, 46: 2596–2598
Zhang M, Yin B C, Tan W, et al. A versatile graphene-based fluorescence “on/off” switch for multiplex detection of various targets. Biosens Bioelectron, 2011, 26: 3260–3265
Rich R L, Myszka D G. Survey of the year 2007 commercial optical biosensor literature. J Mol Recognit, 2008, 21: 355–400
Roh S, Chung T, Lee B. Overview of the characteristics of micro- and nano-structured surface plasmon resonance sensors. Sensors, 2011, 11: 1565–1588
Willets K A, Van Duyne R P. Localized surface plasmon resonance spectroscopy and sensing. Annu Rev Phys Chem, 2007, 58: 267–297
Anker J N, Hall W P, Lyandres O, et al. Biosensing with plasmonic nanosensors. Nat Mater, 2008, 7: 442–453
Jensen T R, Malinsky M D, Haynes C L, et al. Nanosphere lithography: Tunable localized surface plasmon resonance spectra of silver nanoparticles. J Phys Chem B, 2000, 104: 10549–10556
Miller M M, Lazarides A A. Sensitivity of metal nanoparticle surface plasmon resonance to the dielectric environment. J Phys Chem B, 2005, 109: 21556–21565
Jung L S, Campbell C T, Chinowsky T M, et al. Quantitative interpretation of the response of surface plasmon resonance sensors to adsorbed films. Langmuir, 1998, 14: 5636–5648
Haes A J, Van Duyne R P. A nanoscale optical biosensor: Sensitivity and selectivity of an approach based on the localized surface plasmon resonance spectroscopy of triangular silver nanoparticles. J Am Chem Soc, 2002, 124: 10596–10604
Zhao J, Jensen L, Sung J H, et al. Interaction of plasmon and molecular resonances for rhodamine 6G adsorbed on silver nanoparticles. J Am Chem Soc, 2007, 129: 7647–7656
Haes A J, Zou S L, Zhao J, et al. Localized surface plasmon resonance spectroscopy near molecular resonances. J Am Chem Soc, 2006, 128: 10905–10914
Zhao J, Das A, Zhang X Y, et al. Resonance surface plasmon spectroscopy: Low molecular weight substrate binding to cytochrome P450. J Am Chem Soc, 2006, 128: 11004–11005
Mitchell J S, Wu Y, Cook C J, et al. Sensitivity enhancement of surface plasmon resonance biosensing of small molecules. Anal Biochem, 2005, 343: 125–135
Byun K M. Development of nanostructured plasmonic substrates for enhanced optical biosensing. J Opt Soc Korea, 2010, 14: 65–76
Lyon L A, Musick M D, Natan M J. Colloidal Au-enhanced surface plasmon resonance immunosensing. Anal Chem, 1998, 70: 5177–5183
Liu X, Sun Y, Song D Q, et al. Sensitivity-enhancement of wavelength-modulation surface plasmon resonance biosensor for human complement factor 4. Anal Biochem, 2004, 333: 99–104
Reinhard B M, Siu M, Agarwal H, et al. Calibration of dynamic molecular rulers based on plasmon coupling between gold nanoparticles. Nano Lett, 2005, 5: 2246–2252
Sönnichsen C, Reinhard B M, Liphardt J, et al. A molecular ruler based on plasmon coupling of single gold and silver nanoparticles. Nat Biotechnol, 2005, 23: 741–745
Liu G L, Yin Y, Kunchakarra S, et al. A nanoplasmonic molecular ruler for measuring nuclease activity and DNA footprinting. Nat Nanotechnol, 2006, 1: 47–52
Hall W P, Ngatia S N, Van Duyne R P. LSPR biosensor signal enhancement using nanoparticle-antibody conjugates. J Phys Chem C, 2011, 115: 1410–1414
Jain P K, El-Sayed M A. Surface plasmon coupling and its universal size scaling in metal nanostructures of complex geometry: Elongated particle pairs and nanosphere trimers. J Phys Chem C, 2008, 112: 4954–4960
Lee T H, Lee S W, Jung J, et al. Signal amplification by enzymatic reaction in an immunosensor based on localized surface plasmon resonance (LSPR). Sensors, 2010, 10: 2045–2053
Sagle L B, Ruvuna L K, Ruemmele J A, et al. Advances in localized surface plasmon resonance spectroscopy biosensing. Nanomedicine, 2011, 6: 1447–1462
Hall W P, Anker J N, Lin Y, et al. A calcium-modulated plasmonic switch. J Am Chem Soc, 2008, 130: 5836–5837
Fujieda R, Yang M. LSPR sensitivity improvement by using cnts/au nanoparticle for bioanalysis. Adv Mater Res, 2012, 403: 4411–4415
Zou W, Liu W W, Luo L M, et al. Detection of nitro explosives via LSPR sensitive silver clusters embedded in porous silica. J Mater Chem, 2012, 22: 12474–12478
Yonzon C R, Jeoung E, Zou S, et al. A comparative analysis of localized and propagating surface plasmon resonance sensors: The binding of concanavalin A to a monosaccharide functionalized self-assembled monolayer. J Am Chem Soc, 2004, 126: 12669–12676
Tourillon G, Dreesen L, Volcke C, et al. Total internal reflection sum-frequency generation spectroscopy and dense gold nanoparticles monolayer: A route for probing adsorbed molecules. Nanotechnology, 2007, 18: 415301–415307
Shen Y R. The Principles of Nonlinear Optics. New York: Wiley-Interscience, 1984. 575–580
Gracias D, Chen Z, Shen Y R, et al. Molecular characterization of polymer and polymer blend surfaces. Combined sum frequency generation surface vibrational spectroscopy and scanning force microscopy studies. Acc Chem Res, 1999, 32: 930–940
Shultz M J, Schnitzer C, Simonelli D, et al. Sum frequency generation spectroscopy of the aqueous interface: Ionic and soluble molecular solutions. Int Rev Phys Chem, 2000, 19: 123–153
Gopalakrishnan S, Liu D, Allen H C, et al. Vibrational spectroscopic studies of aqueous interfaces: Salts, acids, bases, and nanodrops. Chem Rev, 2006, 106: 1155–1175
Perry A, Neipert C, Space B, et al. Theoretical modeling of interface specific vibrational spectroscopy: Methods and applications to aqueous interfaces. Chem Rev, 2006, 106: 1234–1258
Moore F, Richmond G. Integration or segregation: How do molecules behave at oil/water interfaces? Acc Chem Res, 2008, 41: 739–748
Guyot-Sionnest P, Hunt J, Shen Y R. Sum-frequency vibrational spectroscopy of a Langmuir film: Study of molecular orientation of a two-dimensional system. Phys Rev Lett, 1987, 59: 1597–1600
Hunt J, Guyot-Sionnest P, Shen Y R. Observation of CH stretch vibrations of monolayers of molecules optical sum-frequency generation. Chem Phys Lett, 1987, 133: 189–192
Chen Z. Molecular structures of buried polymer interfaces and biological interfaces detected by sum frequency generation vibrational spectroscopy. Acta Phys Chim Sin, 2012, 28: 504–521
Chen Z, Ward R, Tian Y, et al. Interaction of fibrinogen with surfaces of end-group-modified polyurethanes: A surface-specific sum-frequency-generation vibrational spectroscopy study. J Biomed Mater Res, 2002, 62: 254–264
Mermut O, Phillips D C, York R L, et al. In situ adsorption studies of a 14-amino acid leucine-lysine peptide onto hydrophobic polystyrene and hydrophilic silica surfaces using quartz crystal microbalance, atomic force microscopy, and sum frequency generation vibrational spectroscopy. J Am Chem Soc, 2006, 128: 3598–3607
Phillips D C, York R L, Mermut O, et al. Side chain, chain length, and sequence effects on amphiphilic peptide adsorption at hydrophobic and hydrophilic surfaces studied by sum-frequency generation vibrational spectroscopy and quartz crystal microbalance. J Phys Chem C, 2007, 111: 255–261
York R L, Browne W K, Geissler P L, et al. Peptides adsorbed on hydrophobic surfaces-A sum frequency generation vibrational spectroscopy and modeling study. Israel J Chem, 2007, 47: 51–58
Weidner T, Breen N F, Li K, et al. Sum frequency generation and solid-state NMR study of the structure, orientation, and dynamics of polystyrene-adsorbed peptides. Proc Natl Acad Sci USA, 2010, 107: 13288–13293
Weidner T, Apte J S, Gamble L J, et al. Probing the orientation and conformation of α-helix and β-strand model peptides on self-assembled monolayers using sum frequency generation and NEXAFS spec-troscopy. Langmuir, 2009, 26: 3433–3440
Fu L, Ma G, Yan E C Y. In situ misfolding of human islet amyloid polypeptide at interfaces probed by vibrational sum frequency generation. J Am Chem Soc, 2010, 132: 5405–5412
Fu L, Wang Z G, Yan E C Y. Chiral vibrational structures of proteins at interfaces probed by sum frequency generation spectroscopy. Int J Mol Sci, 2011, 12: 9404–9425
Fu L, Liu J, Yan E C Y. Chiral sum frequency generation spectroscopy for characterizing protein secondary structures at interfaces. J Am Chem Soc, 2011, 133: 2545–2552
Jung S Y, Lim S M, Albertorio F, et al. The vroman effect: A molecular level description of fibrinogen displacement. J Am Chem Soc, 2003, 125: 12782–12786
Chen X, Sagle L B, Cremer P S. Urea orientation at protein surfaces. J Am Chem Soc, 2007, 129: 15104–15105
Hall S A, Jena K C, Trudeau T G, et al. Structure of leucine adsorbed on polystyrene from nonlinear vibrational spectroscopy measurements, molecular dynamics simulations, and electronic structure calculations. J Phys Chem C, 2011, 115: 11216–11225
Wang J, Buck S M, Chen Z. The effect of surface coverage on conformation changes of bovine serum albumin molecules at the air-solution interface detected by sum frequency generation vibrational spectroscopy. Analyst, 2003, 128: 773–778
Wang J, Paszti Z, Mark A, et al. Measuring polymer surface ordering differences in air and water by sum frequency generation vibrational spectroscopy. J Am Chem Soc, 2002, 124: 7016–7023
Wang J, Buck S M, Chen Z. Sum frequency generation vibrational spectroscopy studies on protein adsorption. J Phys Chem B, 2002, 106: 11666–11672
Wang J, Clarke M L, Chen X Y, et al. Molecular studies on protein conformations at polymer/liquid interfaces using sum frequency generation vibrational spectroscopy. Surf Sci, 2005, 587: 1–11
Chen X Y, Clarke M L, Wang J, et al. Sum frequency generation vibrational spectroscopy studies on molecular conformation and orientation of biological molecules at interfaces. Int J Mod Phys B, 2005, 19: 691–713
Nguyen K T, King J T, Chen Z. Orientation determination of interfacial β-sheet structures in situ. J Phys Chem B, 2010, 114: 8291–8300
Lee S H, Wang J, Krimm S, et al. Irreducible representation and projection operator application to understanding nonlinear optical phenomena: Hyper-raman, sum frequency generation, and four-wave mixing spectroscopy. J Phys Chem A, 2006, 110: 7035–7044
Ye S J, Li H C, Wei F, et al. Observing a model ion channel gating action in model cell membranes in real time in situ: Membrane potential change induced alamethicin orientation change. J Am Chem Soc, 2012, 134: 6237–6243
Clarke M L, Wang J, Chen Z. Conformational changes of fibrinogen after adsorption. J Phys Chem B, 2005, 109: 22027–22035
Wang J, Chen X Y, Clarke M L, et al. Vibrational spectroscopic studies on fibrinogen adsorption at polystyrene/protein solution interfaces: Hydrophobic side chain and secondary structure changes. J Phys Chem B, 2006, 110: 5017–5024
Chen X Y, Wang J, Paszti Z, et al. Ordered adsorption of coagulation factor XII on negatively charged polymer surfaces probed by sum frequency generation vibrational spectroscopy. Anal Bioanal Chem, 2007, 388: 65–72
Han X, Soblosky L, Slutsky M, et al. Solvent effect and time-dependent behavior of c-terminus-cysteine-modified cecropin p1 chemically immobilized on a polymer surface. Langmuir, 2011, 27: 7042–7051
Weeraman C, Yatawara A K, Bordenyuk A N, et al. Effect of nanoscale geometry on molecular conformation: Vibrational sum-frequency generation of alkanethiols on gold nanoparticles. J Am Chem Soc, 2006, 128: 14244–14245
Bordenyuk A N, Weeraman C, Yatawara A, et al. Vibrational sum frequency generation spectroscopy of dodecanethiol on metal nanoparticles. J Phys Chem C, 2007, 111: 8925–8933
Kawai T, Neivandt D J, Davies P B. Sum frequency generation on surfactant-coated gold nanoparticles. J Am Chem Soc, 2000, 122: 12031–12032
Aliaga C, Tsung C K, Alayoglu S, et al. Sum frequency generation vibrational spectroscopy and kinetic study of 2-methylfuran and 2,5-dimethylfuran hydrogenation over 7 nm platinum cubic nanoparticles. J Phys Chem C, 2011, 115: 8104–8109
Yeganeh M S, Dougal S M, Silbernagel B G. Sum frequency generation studies of surfaces of high-surface-area powdered materials. Langmuir, 2006, 22: 637–641
Kweskin S, Rioux R, Habas S, et al. Carbon monoxide adsorption and oxidation on monolayer films of cubic platinum nanoparticles investigated by infrared-visible sum frequency generation vibrational spectroscopy. J Phys Chem B, 2006, 110: 15920–15925
Holman J, Ye S, Neivandt D J, et al. Studying nanoparticle-induced structural changes within fatty acid multilayer films using sum frequency generation vibrational spectroscopy. J Am Chem Soc, 2004, 126: 14322–14323
Tourillon G, Dreesen L, Volcke C, et al. Close-packed array of gold nanoparticles and sum frequency generation spectroscopy in total internal reflection: A platform for studying biomolecules and biosensors. J Mater Sci, 2009, 44: 6805–6810
Somorjai G. New model catalysts (platinum nanoparticles) and new techniques (SFG and STM) for studies of reaction intermediates and surface restructuring at high pressures during catalytic reactions. Appl Surf Sci, 1997, 121: 1–19
Dellwig T, Rupprechter G, Unterhalt H, et al. Bridging the pressure and materials gaps: High pressure sum frequency generation study on supported Pd nanoparticles. Phys Rev Lett, 2000, 85: 776–779
Rupprechter G, Freund H J. Adsorbate-induced restructuring and pressure-dependent adsorption on metal nanoparticles studied by electron microscopy and sum frequency generation spectroscopy. Top Catal, 2000, 14: 3–14
Humbert C, Busson B, Abid J P, et al. Self-assembled organic monolayers on gold nanoparticles: A study by sum-frequency generation combined with UV-vis spectroscopy. Electrochim Acta, 2005, 50: 3101–3110
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Zhang, X., Han, X., Wu, F. et al. Nano-bio interfaces probed by advanced optical spectroscopy: From model system studies to optical biosensors. Chin. Sci. Bull. 58, 2537–2556 (2013). https://doi.org/10.1007/s11434-013-5700-y
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DOI: https://doi.org/10.1007/s11434-013-5700-y