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An efficient synthesis of isocoumarins via a CuI catalyzed cascade reaction process

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Abstract

3-Alkyl isocoumarins are provided by CuI/amino acid-catalyzed Sonogashira coupling reaction of o-bromo benzoic acids and terminal alkynes and the subsequent additive cyclization. This cascade process allows synthesis of diverse isocoumarins by varying both coupling partners bearing a wide range of functional groups.

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Authors and Affiliations

  1. Shenyang Pharmaceutical University, Shenyang, 110016, China

    LeiLei Wang & XiaoJing Zhang

  2. State Key Laboratory of Bioorganic Chemistry and Natural Products, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China

    YongWen Jiang & DaWei Ma

Authors
  1. LeiLei Wang
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  2. XiaoJing Zhang
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  3. YongWen Jiang
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  4. DaWei Ma
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Correspondence to DaWei Ma.

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Supported by the National Natural Science Foundation of China (Grant Nos. 20621062 & 20872156)

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Wang, L., Zhang, X., Jiang, Y. et al. An efficient synthesis of isocoumarins via a CuI catalyzed cascade reaction process. Sci. China Ser. B-Chem. 52, 1616–1621 (2009). https://doi.org/10.1007/s11426-009-0197-6

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  • DOI: https://doi.org/10.1007/s11426-009-0197-6

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