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Three new ent-kaurane diterpenes from the herbs of Wedelia prostrata

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Abstract

Three new ent-kaurane diterpenes, 3α-angeloyloxy-17-hydroxy-ent-kaur-15-en-19-oic acid (1), 3α-tigloyloxy-17-hydroxy-ent-kaur-15-en-19-oic acid (2) and 3α-cinnamoyloxykaur-9(11),16-dien-19-oic acid (3), along with five known compounds (4-8), were isolated from the herbs of Wedelia prostrata (Asteraceae). The structures were determined by extensive analysis of their spectroscopic data (IR, UV, HRESIMS, 1D and 2D NMR). The isolated compounds were evaluated for their cytotoxic activity on human hepatocellular carcinoma HepG2 cells. Among them, all isolates exhibited cytotoxic activities with IC50 values ranging from 9.55 ± 0.45 to 53.92 ± 1.22 μM.

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Acknowledgments

This work was supported financially by the Natural Science Foundations of China (Nos. 81673319, 81202429, 81273390 and 81473116), the Natural Science Foundation of Guangdong Province (No. S2013020012864) and 111 Project (No. B13038).

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Authors and Affiliations

  1. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, People’s Republic of China

    Zhongnan Wu, Yubo Zhang, Li Yang, Nenghua Chen, Lin Jiang, Siqi Jiang, Guoqiang Li, Yaolan Li & Guocai Wang

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  1. Zhongnan Wu
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  2. Yubo Zhang
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  3. Li Yang
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  4. Nenghua Chen
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  5. Lin Jiang
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  6. Siqi Jiang
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  7. Guoqiang Li
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  8. Yaolan Li
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  9. Guocai Wang
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Correspondence to Yaolan Li or Guocai Wang.

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Wu, Z., Zhang, Y., Yang, L. et al. Three new ent-kaurane diterpenes from the herbs of Wedelia prostrata . J Nat Med 71, 305–309 (2017). https://doi.org/10.1007/s11418-016-1037-6

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  • DOI: https://doi.org/10.1007/s11418-016-1037-6

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