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The renin–angiotensin system and prevention of age-related functional decline: where are we now?

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Abstract

Declining physical function is a major health problem for older adults as it is associated with multiple comorbidities and mortality. Exercise has been shown to improve physical function, though response to exercise is variable. Conversely, drugs targeting the renin–angiotensin system (RAS) pathway, including angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs), are also reported to improve physical function. In the past decade, significant strides have been made to understand the complexity and specificity of the RAS system as it pertains to physical function in older adults. Prior findings have also determined that interactions between antihypertensive medications and exercise may influence physical function above and beyond either factor alone. We review the latest research on RAS, exercise, and physical function for older adults. We also outline future research aims in this area, including genetic influences and clinical phenotyping, for the purpose of maintaining or improving physical function through tailored treatments.

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Acknowledgments

This work was supported by grants from Claude D. Pepper Older Americans Independence Centers (University of Florida, P30AG028740), University of Florida Clinical and Translational Science Institute (National Center for Research Resources, UL1RR029890, KL2RR029888), and NIH/NCATS Clinical and Translational Science Awards to the University of Florida (TL1 TR000066 and UL1 TR000064).

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Authors and Affiliations

  1. Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, USA

    Corey B. Simon

  2. Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL, USA

    Brittany Lee-McMullen

  3. Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA

    Dane Phelan

  4. Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA

    Janine Gilkes

  5. Department of Aging and Geriatric Research, College of Medicine, University of Florida, Gainesville, FL, USA

    Christy S. Carter & Thomas W. Buford

  6. Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL, USA

    Thomas W. Buford

Authors
  1. Corey B. Simon
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  2. Brittany Lee-McMullen
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  3. Dane Phelan
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  4. Janine Gilkes
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  5. Christy S. Carter
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  6. Thomas W. Buford
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Correspondence to Thomas W. Buford.

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Simon, C.B., Lee-McMullen, B., Phelan, D. et al. The renin–angiotensin system and prevention of age-related functional decline: where are we now?. AGE 37, 13 (2015). https://doi.org/10.1007/s11357-015-9753-5

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  • DOI: https://doi.org/10.1007/s11357-015-9753-5

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