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IGF-1: a potential biomarker for efficacy of sleep improvement with automatic airway pressure therapy for obstructive sleep apnea?

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Abstract

Background

Positive airway pressure (PAP) reverses obstructive sleep apnea (OSA)-related hypoxia and restores slow wave sleep (SWS). Insulin-like growth factor 1 (IGF-1) is a neuropeptide that facilitates the repair of neurons from hypoxia and improves sleep regulation. IGF-1 concentrations are lower in OSA, and likely increase following PAP treatment; however, this relationship has not yet been determined in a younger cohort of OSA patients.

Methods

This was a prospective, observational pilot study of 58 young men, who were diagnosed with OSA and provided PAP as an intervention. Adherence to PAP treatment over 3 months was objectively measured, as well as changes in the apnea–hypopnea index (AHI). Serum concentrations of IGF-1and C-reactive protein (CRP) were measured and correlated with PAP adherence.

Results

IGF-1 concentrations at baseline were similar between PAP adherent 55.5 ± 34.4 ng/ml and PAP nonadherent participants 61.2 ± 27.1 ng/ml (p = 0.4), with the overall mean IGF-1 concentration of 59.0 ± 29.9 ng/ml. At follow-up, adherent participants had concentrations of IGF-1 that were significantly higher 128 ± 59.5 ng/ml compared to nonadherent participants 86.0 ± 47.4 ng/ml (p < 0.01). Increases in IGF-1 concentrations were significantly associated with reductions in AHI (Spearman’s rho = −0.409, p = 0.015). Conversely, CRP concentrations did not differ between baseline and follow-up measurements in either group.

Conclusions

Adherence to PAP treatment leads to significant increases in IGF-1 concentrations in young men with OSA. While an objective measure of adherence exists, PAP usage does not allow for measure of sleep improvement. IGF-1 may serve as a potential biomarker for the efficacy of PAP therapy on improved sleep.

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Acknowledgments

The opinions and assertions in this manuscript are those of the authors and do not necessarily represent those of the Department of the Army, Department of Defense, US Government, or the Center for Neuroscience and Regenerative Medicine.

Conflict of interest

No author has any conflicts of interest to disclose.

Author information

Authors and Affiliations

  1. Medical Specialties Clinic, 121st General Hospital, Unit #15281, APO AP, 96205-5281, Seoul, Korea

    Vincent Mysliwiec

  2. National Institute of Nursing Research, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA

    Jessica Gill

  3. Department of Operations Research, Naval Postgraduate School, 1411 Cunningham Road, Monterey, CA, 93943, USA

    Panagiotis Matsangas

  4. Department of Pulmonary, Critical Care, Sleep Medicine, Madigan Army Medical Center, 9040A Fitzsimmons Avenue, Tacoma, WA, 98431, USA

    Tristin Baxter & Bernard J. Roth

  5. West Virginia University, 1 Medical Center Drive, Morgantown, WV, 26506, USA

    Taura Barr

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  1. Vincent Mysliwiec
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Correspondence to Bernard J. Roth.

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Mysliwiec, V., Gill, J., Matsangas, P. et al. IGF-1: a potential biomarker for efficacy of sleep improvement with automatic airway pressure therapy for obstructive sleep apnea?. Sleep Breath 19, 1221–1228 (2015). https://doi.org/10.1007/s11325-015-1142-x

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  • DOI: https://doi.org/10.1007/s11325-015-1142-x

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