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Complete genome sequence of a virulent Newcastle disease virus isolated from an outbreak in chickens in Egypt

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Abstract

The complete genome sequence of a virulent Newcastle disease virus (NDV) isolated from chickens in Egypt was determined and compared to the sequence of NDV strains isolated from different parts of the world. The genome is 15,186 nucleotides (nt) long and consists of 6 genes in the order of 3′-N-P-M-F-HN-L-5′. The genome contains a 55-nt leader region at the 3′ end and a 114-nt trailer region at the 5′ end. Interestingly, the phylogenetic analysis showed that strain Egypt is closely related with the NDV strains isolated in China. In addition, the sequence of the fusion protein cleavage site of strain Egypt was identical to that of the NDV strain recently isolated in Mali. Determination of complete genome sequences of additional NDV strains from Africa is necessary to understand the epidemiology of currently circulating viruses in Africa.

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Acknowledgments

We thank Daniel Rockemann and all our laboratory members for their excellent technical assistance. We also thank Ireen Dryburgh-Barry for proofreading the manuscript.

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Authors and Affiliations

  1. Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, 20742, USA

    Mahmoud H. A. Mohamed, Sachin Kumar, Anandan Paldurai & Siba K. Samal

  2. Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt

    Mahmoud H. A. Mohamed, Mohamed M. Megahed, Ibrahim A. Ghanem & Mohamed A. Lebdah

Authors
  1. Mahmoud H. A. Mohamed
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  2. Sachin Kumar
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  3. Anandan Paldurai
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  4. Mohamed M. Megahed
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  5. Ibrahim A. Ghanem
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  6. Mohamed A. Lebdah
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  7. Siba K. Samal
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Correspondence to Siba K. Samal.

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Mohamed, M.H.A., Kumar, S., Paldurai, A. et al. Complete genome sequence of a virulent Newcastle disease virus isolated from an outbreak in chickens in Egypt. Virus Genes 39, 234–237 (2009). https://doi.org/10.1007/s11262-009-0385-7

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  • DOI: https://doi.org/10.1007/s11262-009-0385-7

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